ReviewCurrent opinion in nephrology and hypertension2019
Urinary oxalate as a potential mediator of kidney disease in diabetes mellitus and obesity.
Review in Current opinion in nephrology and hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Contributions of the anion exchangers SLC26A1, SLC26A2, SLC26A3, and SLC26A6 to intestinal oxalate transport in human Caco2-BBE cells.Physiological reports · 2026Article
- A 64-Year-Old Woman with Diabetes Mellitus Associated with Increased Urinary Oxalate Excretion Presenting with Acute Kidney Injury Due to Acute Oxalate Nephropathy.The American journal of case reports · 2025Article
- Associations of obesity, sarcopenia, and sarcopenic obesity with the risk of kidney stones in the U.S. Adult: results from NHANES 2011-2018.Urolithiasis · 2025Article
- Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.eLife · 2025Article
- Article
- The Multidisciplinary Approach in the Management of Patients with Kidney Stone Disease-A State-of-the-Art Review.Nutrients · 2024Review
- Twenty-four-hour urine oxalate and risk of chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Observational
- Application of Clinical Blood Metabogram to Type 2 Diabetes Mellitus.Metabolites · 2024Article
- Association between weight-adjusted waist index and kidney stones: a propensity score matching study.Frontiers in endocrinology · 2024Article
- Oxalate Nephropathy and the Mechanism of Oxalate-Induced Kidney Injury.Kidney diseases (Basel, Switzerland) · 2023Review
- Sel1-like proteins and peptides are the majorAmerican journal of physiology. Cell physiology · 2023Article
- Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives.Biomedicines · 2023Review
- Secondary oxalate nephropathy and impact of high-dose vitamin C intake for COVID-19 prevention on a patient with Roux-en-Y gastric bypass: A case report.Clinical case reports · 2023Article
- Oxalate homeostasis.Nature reviews. Nephrology · 2023Review
- In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact.Frontiers in medicine · 2023Article
- Increased Rates of Supplement-Associated Oxalate Nephropathy During COVID-19 Pandemic.Kidney international reports · 2022Article
- Clinical characterization of primary hyperoxaluria type 3 in comparison with types 1 and 2.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Oxalate nephropathy: a review.Clinical kidney journal · 2022Article
- Acute oxalate nephropathy: A potential cause of acute kidney injury in diabetes mellitus-A case series from a single center.Frontiers in medicine · 2022Article
- Critically ill, tubular injury, delayed early recovery: characteristics of acute kidney disease with renal oxalosis.Renal failure · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewHyperoxaluria can cause kidney disease through multiple mechanisms, including tubular obstruction from calcium oxalate crystals, sterile inflammation, and tubular epithelial cell injury. Hyperoxaluria is also observed in individuals with diabetes mellitus and obesity, which are in turn risk factors for chronic kidney disease (CKD). Whether hyperoxaluria is a potential mediator of increased risk of CKD in diabetes mellitus and obesity is unknown. RECENT
findingsIndividuals with diabetes have increased levels of plasma glyoxal (a protein glycation product) and glyoxylate, both of which are precursors for oxalate. Increased gut absorption of oxalate in obesity may be because of obesity-associated inflammation. A recent study in individuals with CKD found that higher 24 h urinary oxalate excretion was independently associated with increased risk of kidney disease progression, especially in individuals with diabetes and obesity. SUMMARY: Both diabetes mellitus and obesity are associated with higher urinary oxalate excretion through distinct mechanisms. Hyperoxaluria could be a mechanism by which kidney disease develops in individuals with diabetes mellitus or obesity and could also contribute to progressive loss of renal function. Future research on pharmacologic or dietary measures to limit oxalate absorption or generation are required to test whether lowering urinary oxalate excretion is beneficial in preventing kidney disease development and progression in diabetes mellitus and obesity.
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