SynthesisHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2019
Multimorbidity in randomized controlled trials of behavioral interventions: A systematic review.
Synthesis in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Substance Use Within Trials of Psychological Interventions for Psychosis: Sample Inclusion, Secondary Measures, and Intervention Effectiveness.Schizophrenia bulletin · 2024Pooled it
- Proof of Concept of a 6-Month Person-Oriented Exercise Intervention 'MultiPill-Exercise' among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial.International journal of environmental research and public health · 2022Trial
- Article
- Toward Digital Self-Monitoring of Mental Health in the General Population: Scoping Review of Existing Approaches to Self-Report Measurement.JMIR mental health · 2025Article
- Deep learning reveals that multidimensional social status drives population variation in 11,875 US participant cohort.PloS one · 2025Article
- Harnessing population diversity: in search of tools of the trade.GigaScience · 2024Article
- Illness Perception and the Severity of Depression and Anxiety Symptoms in Patients with Multimorbidity: Observational Cohort Studies.Journal of clinical medicine · 2023Article
- CHRONIC MULTIMORBIDITY OF LOW BACK PAIN OR OTHER CHRONIC BACK DISORDERS IN THE REPUBLIC OF CROATIA.Acta clinica Croatica · 2023Article
- Associations between daily step count trajectories and clinical outcomes among adults with comorbid obesity and depression.Mental health and physical activity · 2023Article
- Multimorbidity in Difficult Asthma: The Need for Personalised and Non-Pharmacological Approaches to Address a Difficult Breathing Syndrome.Journal of personalized medicine · 2022Review
- Making Pain Research More Inclusive: Why and How.The journal of pain · 2022Review
- Discrimination and Multimorbidity Among Black Americans: Findings from the National Survey of American Life.Journal of racial and ethnic health disparities · 2021Article
- The value of a second reviewer for study selection in systematic reviews.Research synthesis methods · 2019Article
- Multimorbidity: Implications and directions for health psychology and behavioral medicine.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Prioritising and ranking methodological uncertainties in the design, conduct, and analysis of trials aiming to improve health outcomes for those living with multiple long-term conditions: A protocol for a modified Delphi study.Journal of multimorbidity and comorbidityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveAs the population with multiple chronic conditions (MCC) increases, it is essential that randomized controlled trials (RCTs) consider MCC. Behavioral interventions have the potential to positively impact MCC patient outcomes; however, a comprehensive review of consideration of MCC in these trials has not been conducted. The purpose of this systematic review is to determine the frequency with which participants with MCC are represented in behavioral intervention RCTs targeting chronic illness published 2000-2014.
methodMEDLINE and EMBASE were searched from 2000 to 2014 to identify RCTs testing behavioral interventions among adults with chronic illness. A random sampling selection process was performed to identify 600 eligible studies representative of the literature. Two reviewers independently extracted information on consideration of MCC in eligibility criteria and evaluated the reporting and consideration of MCC in trial analyses. Risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool.
resultsIn 600 behavioral intervention RCTs, targeting MCC was rare (4.3%). Exclusion of MCC was common (68.3%) and was done through general, specific, or vague exclusion criteria. 218 (36.3%) trials reported presence of MCCs through general or condition-specific measures. Comorbidities were only considered in 4.8% of all trial analyses.
conclusionsIn this comprehensive systematic review of 600 studies published from 2000-2014, RCTs testing behavioral interventions rarely consider individuals with MCC, limiting generalizability. Given the public health relevance and limited evidence base, this work highlights the urgent need to improve the consideration of MCC in clinical trial research. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.