ArticleAnalytical chemistry2019
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.
Abstract readMulticenter Study
In one paragraph
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65citing papers in PubMed
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65 citing papers in PubMed.
- Quantitative interactome mapping of skeletal muscle insulin resistance.Molecular systems biology · 2026Article
- FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators.The EMBO journal · 2026Article
- FAIMS-GPF XL-MS: crosslinking-mass spectrometry based on gas-phase fractionation.Nature communications · 2026Article
- Cross-linking mass spectrometry for structure analysis of the intrinsically disordered Tau and phosphorylated Tau protein.PLoS computational biology · 2026Article
- Towards a universal cross-linking mass spectrometry approach for protein structure analysis with homo-bi-functional photo-activatable cross-linkers.Communications biology · 2025Article
- State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025Review
- Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity.Nature communications · 2025Article
- Trioxane-based MS-cleavable cross-linking mass spectrometry for profiling multimeric interactions of cellular networks.Nature communications · 2025Article
- A highly sensitive protein-RNA cross-linking mass spectrometry workflow with enhanced structural modeling potential.Nucleic acids research · 2025Article
- Mapping the interaction surface between CaNature communications · 2025Article
- Structural insights into the role of the proline rich region in tau function.Structure (London, England : 1993) · 2025Article
- Versatile Features of an Antibody Mimetic Peptide and Its Variants.Journal of peptide science : an official publication of the European Peptide Society · 2025Article
- Locating Polyubiquitin Receptors on the 19S Regulatory Proteasome ofJournal of the American Society for Mass Spectrometry · 2025Article
- A Photo-Caged Cross-Linker for Identifying Protein-Protein Interactions.Chembiochem : a European journal of chemical biology · 2024Article
- Top-down mass spectrometry of native proteoforms and their complexes: a community study.Nature methods · 2024Article
- Spatially resolved profiling of protein conformation and interactions by biocompatible chemical cross-linking in living cells.Nature communications · 2024Article
- High-Performance Workflow for Identifying Site-Specific Crosslinks Originating from a Genetically Incorporated, Photoreactive Amino Acid.Journal of proteome research · 2024Article
- Chemical cross-linking and mass spectrometry enabled systems-level structural biology.Current opinion in structural biology · 2024Review
- Mapping the Intersubunit Interdomain FMN-Heme Interactions in Neuronal Nitric Oxide Synthase by Targeted Quantitative Cross-Linking Mass Spectrometry.Biochemistry · 2024Article
- A Workflow for Improved Analysis of Cross-Linking Mass Spectrometry Data Integrating Parallel Accumulation-Serial Fragmentation with MeroX and Skyline.Analytical chemistry · 2024Article
5 more citing papers are in PubMed but not listed here.
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Authors and funding
74 authors.
Claudio IacobucciDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.
Christine PiotrowskiDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.
Ruedi AebersoldDepartment of Biology, Institute of Molecular Systems Biology , ETH Zurich , Otto-Stern-Weg 3 , 8093 Zurich , Switzerland.
Bruno C AmaralInstitute of Chemistry , University of Campinas , Campinas São Paulo 13083-970 , Brazil.
Philip AndrewsDepartments of Biological Chemistry, Bioinformatics, and Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Katja BernfurDepartment of Biochemistry and Structural Biology, Center for Molecular Protein Science , Lund University , 221 00 Lund , Sweden.
Christoph BorchersUniversity of Victoria-Genome British Columbia Proteomics Centre , Vancouver Island Technology Park , Victoria , British Columbia V8Z 7X8 , Canada.ORCID 0000-0003-2394-6512
Nicolas I BrodieUniversity of Victoria-Genome British Columbia Proteomics Centre , Vancouver Island Technology Park , Victoria , British Columbia V8Z 7X8 , Canada.
James E BruceDepartment of Genome Sciences , University of Washington , Seattle , Washington 98195 , United States.ORCID 0000-0001-6441-6089
Yong CaoNational Institute of Biological Sciences , Beijing 7 Science Park Road, ZGC Life Science Park , 102206 Beijing , China.
Stéphane ChaignepainCBMN, UMR 5248, CNRS , Université de Bordeaux, INP Bordeaux , Pessac 33607 , France.
Juan D ChavezDepartment of Genome Sciences , University of Washington , Seattle , Washington 98195 , United States.
Stéphane ClaverolCentre de Génomique Fonctionnelle, Plateforme Protéome , Université de Bordeaux , Bordeaux 33000 , France.
Jürgen CoxComputational Systems Biochemistry Research Group , Max-Planck-Institute of Biochemistry , Am Klopferspitz 18 , 82152 Martinsried , Germany.ORCID 0000-0001-8597-205X
Trisha DavisDepartment of Biochemistry , University of Washington , Seattle , Washington 98195 , United States.
Gianluca DegliespostiMRC Laboratory of Molecular Biology , Cambridge Biomedical Campus , Francis Crick Avenue , Cambridge CB2 0QH , U.K.
Meng-Qiu DongNational Institute of Biological Sciences , Beijing 7 Science Park Road, ZGC Life Science Park , 102206 Beijing , China.
Nufar EdingerDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel.
Cecilia EmanuelssonDepartment of Biochemistry and Structural Biology, Center for Molecular Protein Science , Lund University , 221 00 Lund , Sweden.ORCID 0000-0001-8762-477X
Marina GayInstitute for Research in Biomedicine (IRB Barcelona) , The Barcelona Institute of Science and Technology (BIST) , Baldiri Reixac 10 , 08028 Barcelona , Spain.
Michael GötzeInstitute for Biochemistry and Biotechnology, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.
Francisco Gomes-NetoLaboratory of Toxinology , Oswaldo Cruz Institute , Fiocruz, Avenida Brasil 4365 (Moorish Castle) , Manguinhos, Rio de Janeiro , Rio de Janeiro 21040-900 , Brazil.
Fabio C GozzoInstitute of Chemistry , University of Campinas , Campinas São Paulo 13083-970 , Brazil.ORCID 0000-0002-5270-4427
Craig GutierrezDepartment of Physiology & Biophysics , University of California , Irvine , California 92697 , United States.
Caroline HauptInterdisciplinary Research Center HALOmem, Institute for Biochemistry and Biotechnology, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , University of Utrecht and Netherlands Proteomics Centre , Padualaan 8 , 3584 CH Utrecht , The Netherlands.ORCID 0000-0002-2405-4404
Franz HerzogGene Center Munich, Department of Biochemistry, Faculty of Chemistry and Pharmacy , Ludwig Maximilians University of Munich , Feodor-Lynen-Strasse 25 , 81377 Munich , Germany.
Lan HuangDepartment of Physiology & Biophysics , University of California , Irvine , California 92697 , United States.ORCID 0000-0002-3140-4687
Michael R HoopmannInstitute for Systems Biology , 401 Terry Avenue North , Seattle , Washington 98109 , United States.ORCID 0000-0001-7029-7792
Nir KalismanDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel.
Oleg KlykovBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , University of Utrecht and Netherlands Proteomics Centre , Padualaan 8 , 3584 CH Utrecht , The Netherlands.ORCID 0000-0003-4401-9400
Zdeněk KukačkaInstitute of Microbiology , BIOCEV , Prumyslova 595 , 252 50 Vestec , Czech Republic.
Fan LiuLeibniz Institute of Molecular Pharmacology (FMP) , Robert-Rössle-Strasse 10 , 13125 Berlin , Germany.
Michael J MacCossDepartment of Genome Sciences , University of Washington , Seattle , Washington 98195 , United States.
Karl MechtlerProtein Chemistry Facility, Research Institute of Molecular Pathology (IMP) and Institute of Molecular Biotechnology (IMBA) , Vienna Biocenter (VBC) , Dr. Bohr-Gasse 3 , 1030 Vienna , Austria.ORCID 0000-0002-3392-9946
Ravit MesikaDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel.
Robert L MoritzInstitute for Systems Biology , 401 Terry Avenue North , Seattle , Washington 98109 , United States.ORCID 0000-0002-3216-9447
Nagarjuna NagarajBiochemistry Core Facility , Max-Planck-Institute of Biochemistry , Am Klopferspitz 18 , 82152 Martinsried , Germany.
Victor NesatiAnalytical Biochemistry, CSL Limited , Bio21 Institute , 30 Flemington Road , 3010 Parkville, Melbourne , Australia.
Ana G C Neves-FerreiraLaboratory of Toxinology , Oswaldo Cruz Institute , Fiocruz, Avenida Brasil 4365 (Moorish Castle) , Manguinhos, Rio de Janeiro , Rio de Janeiro 21040-900 , Brazil.
Robert NinnisAnalytical Biochemistry, CSL Limited , Bio21 Institute , 30 Flemington Road , 3010 Parkville, Melbourne , Australia.
Petr NovákInstitute of Microbiology , BIOCEV , Prumyslova 595 , 252 50 Vestec , Czech Republic.ORCID 0000-0001-8688-529X
Francis J O'ReillyChair of Bioanalytics, Institute of Biotechnology Technische Universität Berlin , 13355 Berlin , Germany.
Matthias PelzingAnalytical Biochemistry, CSL Limited , Bio21 Institute , 30 Flemington Road , 3010 Parkville, Melbourne , Australia.
Evgeniy PetrotchenkoUniversity of Victoria-Genome British Columbia Proteomics Centre , Vancouver Island Technology Park , Victoria , British Columbia V8Z 7X8 , Canada.
Lolita PiersimoniDepartments of Biological Chemistry, Bioinformatics, and Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Manolo PlasenciaDepartments of Biological Chemistry, Bioinformatics, and Chemistry , University of Michigan , Ann Arbor , Michigan 48109 , United States.
Tara PukalaDiscipline of Chemistry, Faculty of Sciences , University of Adelaide , North Terrace, Adelaide , South Australia 5005 , Australia.ORCID 0000-0001-7391-1436
Kasper D RandDepartment of Pharmacy , University of Copenhagen , 2100 Copenhagen , Denmark.ORCID 0000-0002-6337-5489
Juri RappsilberChair of Bioanalytics, Institute of Biotechnology Technische Universität Berlin , 13355 Berlin , Germany.ORCID 0000-0001-5999-1310
Dana ReichmannDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel.
Carolin SailerUniversity of Konstanz , Department of Biology , Universitätsstrasse 10 , 78457 Konstanz , Germany.
Chris P SarnowskiDepartment of Biology, Institute of Molecular Systems Biology , ETH Zurich , Otto-Stern-Weg 3 , 8093 Zurich , Switzerland.
Richard A ScheltemaBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences , University of Utrecht and Netherlands Proteomics Centre , Padualaan 8 , 3584 CH Utrecht , The Netherlands.ORCID 0000-0002-1668-0253
Carla SchmidtInterdisciplinary Research Center HALOmem, Institute for Biochemistry and Biotechnology, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.ORCID 0000-0001-9410-1424
David C SchriemerDepartment of Biochemistry & Molecular Biology, Robson DNA Science Centre , University of Calgary , 3330 Hospital Drive North West , Calgary , Alberta T2N 4N1 , Canada.ORCID 0000-0002-5202-1618
Yi ShiDepartment of Cell Biology , University of Pittsburgh, School of Medicine , Pittsburgh , Pennsylvania 15213 , United States.
J Mark SkehelMRC Laboratory of Molecular Biology , Cambridge Biomedical Campus , Francis Crick Avenue , Cambridge CB2 0QH , U.K.
Moriya SlavinDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, Safra Campus Givat Ram , The Hebrew University of Jerusalem , Jerusalem 91904 , Israel.
Frank SobottDepartment of Chemistry , University of Antwerp , Groenenborgerlaan 171 , 2020 Antwerp , Belgium.
Victor Solis-MezarinoGene Center Munich, Department of Biochemistry, Faculty of Chemistry and Pharmacy , Ludwig Maximilians University of Munich , Feodor-Lynen-Strasse 25 , 81377 Munich , Germany.
Heike StephanowitzLeibniz Institute of Molecular Pharmacology (FMP) , Robert-Rössle-Strasse 10 , 13125 Berlin , Germany.
Florian StengelUniversity of Konstanz , Department of Biology , Universitätsstrasse 10 , 78457 Konstanz , Germany.
Christian E StiegerProtein Chemistry Facility, Research Institute of Molecular Pathology (IMP) and Institute of Molecular Biotechnology (IMBA) , Vienna Biocenter (VBC) , Dr. Bohr-Gasse 3 , 1030 Vienna , Austria.
Esben TrabjergDepartment of Pharmacy , University of Copenhagen , 2100 Copenhagen , Denmark.
Michael TrnkaUCSF Mass Spectrometry Facility , Genentech Hall, 600 16th Street , San Francisco , California 94158 , United States.
Marta VilasecaInstitute for Research in Biomedicine (IRB Barcelona) , The Barcelona Institute of Science and Technology (BIST) , Baldiri Reixac 10 , 08028 Barcelona , Spain.
Rosa VinerThermo Fisher Scientific , 355 River Oaks Parkway , San Jose , California 95134 , United States.
Yufei XiangDepartment of Cell Biology , University of Pittsburgh, School of Medicine , Pittsburgh , Pennsylvania 15213 , United States.
Sule YilmazComputational Systems Biochemistry Research Group , Max-Planck-Institute of Biochemistry , Am Klopferspitz 18 , 82152 Martinsried , Germany.
Alex ZelterDepartment of Biochemistry , University of Washington , Seattle , Washington 98195 , United States.ORCID 0000-0002-5331-0577
Daniel ZiemianowiczDepartment of Biochemistry & Molecular Biology, Robson DNA Science Centre , University of Calgary , 3330 Hospital Drive North West , Calgary , Alberta T2N 4N1 , Canada.
Alexander LeitnerDepartment of Biology, Institute of Molecular Systems Biology , ETH Zurich , Otto-Stern-Weg 3 , 8093 Zurich , Switzerland.ORCID 0000-0003-4126-0725
Andrea SinzDepartment of Pharmaceutical Chemistry and Bioanalytics, Institute of Pharmacy, Charles Tanford Protein Center , Martin Luther University Halle-Wittenberg , Kurt-Mothes-Strasse 3a , 06120 Halle/Saale , Germany.ORCID 0000-0003-1521-4899
Funding
Proteomics of the Proteasome Interacting NetworksR01GM074830 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2005 to 2022
$6.1MQuantitation of protein interactions in cancer cellsR01GM086688 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRUCE, JAMES EDWARD · 2009 to 2019
$4.2MMedical Research Council MC_U105184326NIGMS NIH HHS R01 GM074830NIGMS NIH HHS R01 GM086688Wellcome Trust 103139/Z/13/Z
Abstract
The number of publications in the field of chemical cross-linking combined with mass spectrometry (XL-MS) to derive constraints for protein three-dimensional structure modeling and to probe protein-protein interactions has increased during the last years. As the technique is now becoming routine for in vitro and in vivo applications in proteomics and structural biology there is a pressing need to define protocols as well as data analysis and reporting formats. Such consensus formats should become accepted in the field and be shown to lead to reproducible results. This first, community-based harmonization study on XL-MS is based on the results of 32 groups participating worldwide. The aim of this paper is to summarize the status quo of XL-MS and to compare and evaluate existing cross-linking strategies. Our study therefore builds the framework for establishing best practice guidelines to conduct cross-linking experiments, perform data analysis, and define reporting formats with the ultimate goal of assisting scientists to generate accurate and reproducible XL-MS results.
Indexed as
Cross-Linking ReagentsLaboratoriesMass SpectrometryReproducibility of ResultsSerum Albumin, BovineCross-Linking ReagentsSerum Albumin, Bovine
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