ArticleACS applied materials & interfaces2019
Reference-Free Traction Force Microscopy Platform Fabricated via Two-Photon Laser Scanning Lithography Enables Facile Measurement of Cell-Generated Forces.
Article in ACS applied materials & interfaces, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Traction Force Microscopy for Viscoelastic Substrates: A Semi-Analytical Method.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Traction Force Microscopy with DNA FluoroCubes.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Inferring cellular contractile forces and work using deep morphology traction microscopy.Biophysical journal · 2024Article
- Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors.Microsystems & nanoengineering · 2024Review
- Nanocomposite Hydrogels as Functional Extracellular Matrices.Gels (Basel, Switzerland) · 2023Review
- The biochemical composition of the actomyosin network sets the magnitude of cellular traction forces.Molecular biology of the cell · 2021Article
- Imaging methods in mechanosensing: a historical perspective and visions for the future.Molecular biology of the cell · 2021Review
- Astigmatic traction force microscopy (aTFM).Nature communications · 2021Article
- Two-dimensional TIRF-SIM-traction force microscopy (2D TIRF-SIM-TFM).Nature communications · 2021Article
- Epifluorescence-based three-dimensional traction force microscopy.Scientific reports · 2020Article
- Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology.Advanced healthcare materials · 2020Review
- Biosensors for Studies on Adhesion-Mediated Cellular Responses to Their Microenvironment.Frontiers in bioengineering and biotechnology · 2020Review
- Fabrication and Implementation of a Reference-Free Traction Force Microscopy Platform.Journal of visualized experiments : JoVE · 2019Article
- Recent technological advancements in traction force microscopy.Biophysical reviews · 2019Article
- Fabrication, characterization, and implementation of engineered hydrogels for controlling breast cancer cell phenotype and dormancy.MethodsX · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cells sense and respond to the physical nature of their microenvironment by mechanically probing their surroundings via cytoskeletal contractions. The material response to these stresses can be measured via traction force microscopy (TFM). Traditional TFM platforms present several limitations including variable spatial resolution, difficulty in attaining the full three-dimensional (3D) deformation/stress profile, and the requirement to remove or relax the cells being measured to determine the zero-stress state. To overcome these limitations, we developed a two-photon, photochemical coupling approach to fabricate a new TFM platform that provides high-resolution control over the 3D placement of fluorescent fiducial markers for facile measurement of cell-generated shear and normal components of traction forces. The highly controlled placement of the 3D marker array provides a built-in, zero stress state eliminating the need to perturb the cells being measured while also providing increased throughput. Using this platform, we discovered that the magnitude of cell-generated shear and normal force components are linked both spatially and temporally. The facile nature and increased throughput of measuring cell-generated forces afforded by this new platform will be useful to the mechanotransduction community and others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.