ArticleThe Journal of experimental medicine1987
Expression of c-fos protooncogene in normal human peripheral blood granulocytes.
Article in The Journal of experimental medicine, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 67 citations in OpenAlex.
- Wandering pathways in the regulation of innate immunity and inflammation.Journal of autoimmunity · 2017Review
- Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.The Journal of biological chemistry · 2016Article
- Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines.The Biochemical journal · 1999Article
- Anti-tumoral effect of GM-CSF with or without cytokines and monoclonal antibodies in solid tumors.Medical oncology (Northwood, London, England) · 1996Review
- Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.The Biochemical journal · 1991Article
- Hematopoietic growth factor receptors.Cytotechnology · 1989Article
- Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells.Molecular and cellular biology · 1989Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated by Northern blot analysis the expression of c-fos protooncogene in human peripheral blood polymorphonuclear leukocytes (PMN). Freshly isolated PMN, unlike highly purified circulating lymphoid cells, showed high levels of c-fos transcripts. Appreciable c-fos mRNA was detected in monocytes, but in lesser amounts compared with PMN. Upon exposure to a series of agents that functionally stimulate granulocytes (PMA, inactivated streptococci, TNF, granulocyte and granulocyte/macrophage colony-stimulating factor), a considerable increase in c-fos transcripts was detected. Expression of c-fos in PMN was superinduced by exposure to cycloheximide. These data indicate that the myelomonocytic differentiation pathway c-fos expression is not peculiar to monocytes/macrophages and that PMN may represent a suitable system with which to investigate the link between protooncogene expression and functional activation.
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Registered trials
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