ArticleFEBS letters2019
Intracellular accumulation of staphylopine impairs the fitness of Staphylococcus aureus cntE mutant.
Article in FEBS letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Profiling of genetic determinants required for fitness of community-associated methicillin-resistantMicrobiology spectrum · 2026Article
- Upregulation of metallophore-related genes of community-acquired methicillin-resistant Staphylococcus aureus enhances pathogenicity in BALB/c mice.BMC genomics · 2025Article
- Coupling tRNAGly gene redundancy with staphylococcal cell wall integrity, antibiotic susceptibility, and virulence potential.Nucleic acids research · 2025Article
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- Analysis of genetic requirements and nutrient availability forbioRxiv : the preprint server for biology · 2024Article
- Resisting death by metal: metabolism and Cu/Zn homeostasis in bacteria.Emerging topics in life sciences · 2024Review
- Deciphering the genomic character of the multidrug-resistantAIMS microbiology · 2024Article
- Host subversion of bacterial metallophore usage drives copper intoxication.bioRxiv : the preprint server for biology · 2023Article
- Review
- How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores.Current medicinal chemistry · 2021Review
- Rsp activates expression of the Cnt system in Staphylococcus aureus.BMC microbiology · 2020Article
- Article
- Intracellular Accumulation of Staphylopine Can Sensitize Staphylococcus aureus to Host-Imposed Zinc Starvation by Chelation-Independent Toxicity.Journal of bacteriology · 2020Article
- Iron Metabolism at the Interface between Host and Pathogen: From Nutritional Immunity to Antibacterial Development.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus exports staphylopine (StP), a broad-spectrum metallophore, via the CntE efflux pump. Here, the mechanism of the fitness defect in the ΔcntE mutant under metal depletion was investigated. Deletion of the StP exporter CntE results in a substantial growth defect, and disrupting the StP biosynthesis gene cntL restores growth of the ΔcntE mutant in metal-depleted media. High-resolution mass spectrometry revealed cytoplasmic accumulation of StP and the absence of extracellular StP in the ΔcntE mutant. The fitness defect of the ΔcntE mutant in mouse subcutaneous abscesses is largely due to StP accumulation. Expression of StP biosynthesis genes are upregulated in the ΔcntE mutant under metal starvation induction. In conclusion, failure to efflux StP results in intracellular StP accumulation and substantially impairs the fitness of S. aureus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.