ArticleJournal of the Optical Society of America. A, Optics, image science, and vision2019
Doppler fluctuation spectroscopy of intracellular dynamics in living tissue.
Article in Journal of the Optical Society of America. A, Optics, image science, and vision, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Label-free subcellular imaging with dynamic spectrally encoded confocal microscopy (D-SECM) with subpixel jitter correction.Biomedical optics express · 2026Article
- Review of dynamic optical coherence tomography for intracellular motility: signals, metrics, and their applications [Invited].Biomedical optics express · 2025Review
- Mapping of blood flow and slow speckle tissue dynamics using laser speckle contrast imaging.Biomedical optics express · 2025Article
- Phase-sensitive dynamic micro-optical coherence tomography for high-speed intracellular motion imaging.Optics letters · 2025Article
- Intracellular doppler spectroscopy of live tissue sentinels for a fast in-vitro bacterial infection assay.Scientific reports · 2025Article
- Comparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies.Scientific reports · 2024Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
- Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma.Frontiers in oncology · 2024Article
- Measurements of slow tissue dynamics with short-separation speckle contrast optical spectroscopy.Biomedical optics express · 2023Article
- Imaging and characterization of transitions in biofilm morphology via anomalous diffusion following environmental perturbation.Biomedical optics express · 2022Article
- Biodynamic signatures from ex vivo bone marrow aspirates are associated with chemotherapy-induced neutropenia in cancer-bearing dogs.Veterinary medicine and science · 2021Article
- Cancer Holography for Personalized Medicine.Optics and photonics news · 2021Article
- Common-path interferometer for digital holographic Doppler spectroscopy of living biological tissues.Journal of biomedical optics · 2021Article
- Doppler imaging detects bacterial infection of living tissue.Communications biology · 2021Article
- Biodynamic digital holographic speckle microscopy for oocyte and embryo metabolic evaluation.Applied optics · 2021Article
- Intracellular optical doppler phenotypes of chemosensitivity in human epithelial ovarian cancer.Scientific reports · 2020Article
- Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue.Journal of biomedical optics · 2020Article
- Tracking the invasion of breast cancer cells in paper-based 3D cultures by OCT motility analysis.Biomedical optics express · 2020Article
- Intracellular Doppler Spectroscopy detects altered drug response in SKOV3 tumor spheroids with silenced or inhibited P-glycoprotein.Biochemical and biophysical research communications · 2019Article
- Biodynamic optical assay for embryo viability.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Intracellular dynamics in living tissue are dominated by active transport driven by bioenergetic processes far from thermal equilibrium. Intracellular constituents typically execute persistent walks. In the limit of long mean free paths, the persistent walks are ballistic, exhibiting a "Doppler edge" in light scattering fluctuation spectra. At shorter transport lengths, the fluctuations are described by lifetime-broadened Doppler spectra. Dynamic light scattering from transport in the ballistic, diffusive, or the crossover regimes is derived analytically, including the derivation of autocorrelation functions through a driven damped harmonic oscillator analog for light scattering from persistent walks. The theory is validated through Monte Carlo simulations. Experimental evidence for the Doppler edge in three-dimensional (3D) living tissue is obtained using biodynamic imaging based on low-coherence interferometry and digital holography.
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Registered trials
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