Evidence map›Paper›PMID 31044749›Full record

SynthesisSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

The effect of using simethicone with or without N-acetylcysteine before gastroscopy: A meta-analysis and systemic review.

Yuanfa Li, Fangjuan Du, Dou Fu

2 registry-linked trialsOpen access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06218537 nacompletednot on this map

The Role of oAncreatic Enzyme ReplAcement Therapy (PERT) on Mucosal Visibility Before Upper GI Endoscopy

TypeinterventionalSponsorCarol Davila University of Medicine and PharmacyRan2024 to 2024Enrolled42ConditionsUpper Gastrointestinal EndoscopyArmsTest group, Control group
NCT07245095 phase2recruitingnot on this map

Randomized Controlled Trial to Evaluate the Effect of Premedication With N-acetylcysteine and Simethicone on Mucosal Visibility During Elective Upper Gastrointestinal Endoscopy Using the TUGS Score

TypeinterventionalSponsorHospital General de MexicaliRan2025 to 2026Enrolled132ConditionsEsophagogastroduodenoscopy, Simethicone, N-Acetylcysteine, PremedicationArmsPremedication with n-acetylcysteine, Placebo (drinking water), Premedication with simethicone
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yuanfa LiDepartment of Gastroenterology, Xiantao First People's Hospital, China.
Fangjuan DuDepartment of Gastroenterology, Liaocheng Second People's Hospital, China.
Dou FuInternal Medicine, Xiantao First People's Hospital, China.
Xiaogan First People's Hospital · CNFourth People's Hospital of Liaocheng · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimTo assess the efficacy and safety of simethicone with or without N-acetylcysteine (NAC) as premedications before gastroscopy. MATERIALS AND

methodsWe searched EMBASE, PubMed, Cochrane library and Web of Science database for randomized clinical controlled trials regarding simethicone ± NAC as oral drinking agents before gastroscopy. Statistical software RevMan5.3 was used for statistical analysis.

resultsTen randomized clinical trials that fulfilled the inclusion criteria were further pooled into a meta-analysis, which included 5,750 patients. The rate of positive findings in simethicone plus NAC group was higher than that in water group (risk ratio [RR] =1.31, 95%CI: 1.12-1.53, P = 0.0006) with high level of evidence. There was no significant difference on the rate of positive findings when comparing simethicone with simethicone plus NAC (RR = 1.02, 95%CI: 0.90-1.16, P = 0.71) and with water (RR = 1.13, 95%CI: 0.82-1.55, P = 0.46), respectively. Simethicone plus NAC showed better total mucosal visibility score than simethicone alone (MD = -0.14 (-0.25, -0.03), P = 0.01) without obvious heterogeneity. Both simethicone plus NAC and simethicone alone offer more benefit than water. The procedure time in simethicone group was shorter than that in water group (MD = -1.23 (-1.51, -0.96), P < 0.00001). Regarding adverse events, there was no significant difference in simethicone and water group (RR = 0.45, 95%CI: 0.2-1.0, P = 0.05, I

conclusionsAs premedication of gastroscopy, simethicone plus NAC offers more benefit on positive findings and total mucosal visibility score.

Indexed as

AcetylcysteineAntifoaming AgentsFree Radical ScavengersGastroscopyHumansPremedicationSimethiconeAcetylcysteineAntifoaming AgentsFree Radical ScavengersSimethiconeGastroscopymeta-analysisN-acetylcysteinepremedicationsimethicone

Identifiers

PMID31044749
PMCPMC6714471
OpenAlexW2969780760

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.