Evidence map›Paper›PMID 31044723›Full record

ReviewThe Lancet. Oncology2019

Digital pathology and artificial intelligence.

Muhammad Khalid Khan Niazi, Anil V Parwani, Metin N Gurcan

Abstract readReview
In one paragraph

Review in The Lancet. Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 581 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
581citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

581 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
  7. FFPE-CUTAC: A Single Assay, Multiple Layers.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

521 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Muhammad Khalid Khan NiaziCenter for Biomedical Informatics, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: mniazi@wakehealth.edu.
Anil V ParwaniDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Metin N GurcanCenter for Biomedical Informatics, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Funding

Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
Computer-based assessment of tumor microenvironment (TME) in Follicular LymphomaR01CA134451 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GURCAN, METIN NAFI, LOZANSKI, GERARD · 2009 to 2017
$2.3M
Informatics Tools for Quantitative Digital Pathology Profiling and Integrated Prognostic ModelingU01CA220401 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI COOPER, LEE, FLOWERS, CHRISTOPHER R · 2018 to 2021
$1.3M
NCI NIH HHS R01 CA134451NCI NIH HHS U01 CA220401NCI NIH HHS U24 CA199374
6 · The paper itself

Abstract

In modern clinical practice, digital pathology has a crucial role and is increasingly a technological requirement in the scientific laboratory environment. The advent of whole-slide imaging, availability of faster networks, and cheaper storage solutions has made it easier for pathologists to manage digital slide images and share them for clinical use. In parallel, unprecedented advances in machine learning have enabled the synergy of artificial intelligence and digital pathology, which offers image-based diagnosis possibilities that were once limited only to radiology and cardiology. Integration of digital slides into the pathology workflow, advanced algorithms, and computer-aided diagnostic techniques extend the frontiers of the pathologist's view beyond a microscopic slide and enable true utilisation and integration of knowledge that is beyond human limits and boundaries, and we believe there is clear potential for artificial intelligence breakthroughs in the pathology setting. In this Review, we discuss advancements in digital slide-based image diagnosis for cancer along with some challenges and opportunities for artificial intelligence in digital pathology.

Indexed as

Artificial IntelligenceDiagnosis, Computer-AssistedImage Interpretation, Computer-AssistedMicroscopyPathologyHumansNeoplasmsPredictive Value of TestsPrognosisReproducibility of ResultsWorkflow

Identifiers

PMID31044723
PMCPMC8711251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.