Evidence map›Paper›PMID 31044666›Full record

ArticleTissue engineering. Part A2020

Amorphous Silicon Oxynitrophosphide-Coated Implants Boost Angiogenic Activity of Endothelial Cells.

Felipe A do Monte, Kamal R Awad, Neelam Ahuja, Harry K W Kim, Pranesh Aswath, Marco Brotto, Venu G Varanasi

Open access · bronzeAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. SiONAntioxidants (Basel, Switzerland) · 2024
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Research progress of vascularization strategies of tissue-engineered bone.Frontiers in bioengineering and biotechnology · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Felipe A do MonteDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas.
Kamal R AwadDepartment of Materials Science and Engineering, University of Texas at Arlington, Arlington, Texas.
Neelam AhujaBone-Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
Harry K W KimCenter for Excellence in Hip Disorders, Texas Scottish Rite Hospital, Dallas, Texas.
Pranesh AswathDepartment of Materials Science and Engineering, University of Texas at Arlington, Arlington, Texas.
Marco BrottoBone-Muscle Research Center, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas.
Venu G VaranasiDepartment of Materials Science and Engineering, University of Texas at Arlington, Arlington, Texas.
The University of Texas at Arlington · USThe University of Texas Southwestern Medical Center · US

Funding

Printing and Regenerating Fractured Bone Using Antioxidant MaterialsR56DE027964 · NIDCR · UNIVERSITY OF TEXAS ARLINGTON · PI VARANASI, VENU GOPAL · 2019 to 2019
$428k
Silicon, a Novel Antioxidant Role in Bone HealingR03DE023872 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI VARANASI, VENU GOPAL · 2014 to 2015
$229k
NIDCR NIH HHS R03 DE023872NIDCR NIH HHS R56 DE027964
6 · The paper itself

Abstract

Lack of osteointegration is a major cause of aseptic loosening and failure of implants used in bone replacement. Implants coated with angiogenic biomaterials can improve osteointegration and potentially reduce these complications. Silicon- and phosphorus-based materials have been shown to upregulate expression of angiogenic factors and improve endothelial cell functions. In the present study, we hypothesize that implants coated with amorphous silica-based coatings in the form of silicon oxynitrophosphide (SiONP) by using plasma-enhanced chemical vapor deposition (PECVD) technique could enhance human umbilical vein endothelial cell angiogenic properties

Indexed as

Angiopoietin-1Biocompatible MaterialsCell ProliferationCells, CulturedCell SurvivalHumansHuman Umbilical Vein Endothelial CellsHypoxia-Inducible Factor 1, alpha SubunitMicrofilament ProteinsNerve Tissue ProteinsReverse Transcriptase Polymerase Chain ReactionSilicon DioxideVascular Endothelial Growth Factor AAngiopoietin-1Biocompatible MaterialsHypoxia-Inducible Factor 1, alpha SubunitMicrofilament ProteinsNerve Tissue ProteinsSilicon DioxideSYNE2 protein, humanVascular Endothelial Growth Factor Aamorphous silicaangiogenesisangiopoietin-1endothelial cellsPECVDSiONPVEGF-A

Identifiers

PMID31044666
PMCPMC6983748
OpenAlexW2942609572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.