Evidence map›Paper›PMID 31044512›Full record

ArticleAging cell2019

Transcriptomic analysis of human IL-7 receptor alpha

Hong-Jai Park, Min Sun Shin, Minhyung Kim, Joshua B Bilsborrow, Subhasis Mohanty, Ruth R Montgomery, Albert C Shaw, Sungyong You, Insoo Kang

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Aging gene signature of memory CD8Immunity & ageing : I & A · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Infectious Complications Predict Premature CD8Journal of clinical immunology · 2021
    Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hong-Jai ParkDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Min Sun ShinDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Minhyung KimDepartments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Joshua B BilsborrowDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Subhasis MohantyDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Ruth R MontgomeryDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Albert C ShawDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Sungyong YouDepartments of Surgery and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
Insoo KangDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.
Yale University · USCedars-Sinai Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
TRAINING PROGRAM IN INVESTIGATIVE RHEUMATOLOGYT32AR007107 · NIAMS · YALE UNIVERSITY · PI RICHARD J BUCALA · 1986 to 2026
$7.5M
The Impact of Aging and HIV Infection on Immunologic and Transcriptomic Signatures of Influenza Vaccine ResponseR01AG055362 · NIA · YALE UNIVERSITY · PI KANG, INSOO, SHAW, ALBERT C · 2017 to 2021
$4.0M
Studying the impact of altered CD8+ T cell immunity in Alzheimer's diseaseR01AG056728 · NIA · YALE UNIVERSITY · PI KANG, INSOO · 2018 to 2022
$2.3M
Midcareer Award in Translational Immunology of AgingK24AG042489 · NIA · YALE UNIVERSITY · PI SHAW, ALBERT C · 2012 to 2022
$1.8M
Studying lupus Th17 cell characteristics and their modulations by IL-27R21AI126604 · NIAID · YALE UNIVERSITY · PI KANG, INSOO · 2016 to 2017
$461k
Aging and IL-7-Mediated CD8+ T Cell SurvivalR56AG028069 · NIA · YALE UNIVERSITY · PI KANG, INSOO · 2015 to 2015
$416k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R21 AI126604NIAID NIH HHS U19 AI089992NIAMS NIH HHS T32 AR007107NIA NIH HHS K24 AG042489NIA NIH HHS P30 AG021342NIA NIH HHS R01 AG055362NIA NIH HHS R01 AG056728NIA NIH HHS R56 AG028069NIH HHS 1R01AG056728NIH HHS 2R56AG0280691NIH HHS K24 AG042489NIH HHS P30 AG021342
6 · The paper itself

Abstract

Here, we investigated the relationship of the age-associated expansion of IL-7 receptor alpha low (IL-7Rα

Indexed as

TranscriptomeAdultAgedAgingCD8-Positive T-LymphocytesCohort StudiesFemaleGene Expression ProfilingGene Regulatory NetworksHealthy VolunteersHumansImmunologic MemoryInfluenza VaccinesMaleMiddle AgedReceptors, Interleukin-7Influenza Vaccinesinterleukin-7 receptor, alpha chainReceptors, Interleukin-7Transcription Factorsagegene expressionhumanIL-7 receptor alphamemory CD8+ T cellsvaccine response

Identifiers

PMID31044512
PMCPMC6612637
OpenAlexW2943237348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.