Evidence map›Paper›PMID 31044423›Full record

Trial reportBritish journal of haematology2019

Multicentre retrospective study of intravascular large B-cell lymphoma treated at academic institutions within the United States.

Marcus Geer, Emily Roberts, Maryann Shango, Brian G Till, Stephen D Smith, Hashim Abbas, Brian T Hill, Jason Kaplan, Paul M Barr, Paolo Caimi and 10 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Cutaneous Intravascular Hematolymphoid Entities: A Review.Diagnostics (Basel, Switzerland) · 2024
    Review
  13. Observational
  14. Article
  15. Article
  16. Intravascular Large B-Cell Lymphoma.Case reports in hematology · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 1 country.

Marcus GeerUniversity of Michigan, Ann Arbor, MI, USA.
Emily RobertsUniversity of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-5838-9691
Maryann ShangoSwedish Cancer Institute, Edmonds, WA, USA.
Brian G TillUniversity of Washington/Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, WA, USA.
Stephen D SmithSeattle Cancer Care Alliance, University of Washington, Seattle, WA, USA.
Hashim AbbasCleveland Clinic Foundation, Cleveland, OH, USA.
Brian T HillDepartment of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.ORCID 0000-0001-8781-3327
Jason KaplanNorthwestern University, Chicago, IL, USA.
Paul M BarrWilmot Cancer Institute, University of Rochester Cancer Center, Rochester, NY, USA.
Paolo CaimiUniversity Hospitals of Cleveland, Cleveland, OH, USA.
Deborah M StephensDivision of Hematology and Hematologic Malignancies, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA.
Emily LinCity of Hope Medical Center, Duarte, CA, USA.
Alex F HerreraDepartment of Medicine, City of Hope, Duarte, CA, USA.ORCID 0000-0002-9665-7415
Evan RosenbaumColumbia University, New York, NY, USA.
Jennifer E AmengualCenter for Lymphoid Malignancies, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Philip S BoonstraUniversity of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-8545-9133
Sumana DevataRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Ryan A WilcoxRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Mark S KaminskiRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
Tycel J PhillipsRogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-2143-9672
University of Michigan · USCleveland Clinic · USSeattle Cancer Care Alliance · USCity of Hope · USCity Of Hope National Medical Center · USColumbia University · USColumbia University Irving Medical Center · USNorthwestern University · USSwedish Medical Center · USUniversity Hospitals of Cleveland · USUniversity of Rochester Medical Center · USUniversity of Utah · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
NCI NIH HHS P30 CA046592
6 · The paper itself

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare entity, with a generally aggressive course that may vary based on geographic presentation. While a United States (US) registry study showed relatively good outcomes with IVLBCL, clinicopathological and treatment data were unavailable. We performed a detailed retrospective review of cases identified at 8 US medical centres, to improve understanding of IVLBCL and inform management. We compiled data retrieved via an Institutional Review Board-approved review of IVLBCL cases identified from 1999 to 2015 at nine academic institutions across the US. We characterized the cohort's clinical status at time of diagnosis, presenting diagnostic and clinical features of the disease, treatment modalities used and overall prognostic data. Our cohort consisted of 54 patients with varying degrees of clinical features. Adjusting for age, better performance status at presentation was associated with increased survival time for the patients diagnosed in vivo (hazard ratio: 2·12, 95% confidence interval 1·28, 3·53). Based on the data we have collected, it would appear that the time interval to diagnosis is a significant contributor to outcomes of patients with IVLBCL.

Indexed as

Academic Medical CentersLymphoma, Large B-Cell, DiffuseAgedAge FactorsDisease-Free SurvivalFemaleHumansMaleMiddle AgedRetrospective StudiesSurvival RateUnited StatesB cellsdiagnostic haematologylymphomas

Identifiers

PMID31044423
PMCPMC8989046
OpenAlexW2943671940

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.