ReviewJBMR plus2019
Heterotopic Ossification: A Comprehensive Review.
Review in JBMR plus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05648916 (The Effect of Celecoxib on Heterotopic Bone Formation Following Cementless Total Hip Arthroplasty), which is not on this map. Cited by 278 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Celecoxib on Heterotopic Bone Formation Following Cementless Total Hip Arthroplasty
Who cites it
278 citing papers in PubMed, 5 syntheses or guidelines pooled it, 477 citations in OpenAlex.
- Non-reconstructive/salvage hip surgery in cerebral palsy: a systematic review.EFORT open reviews · 2026Pooled it
- Periprosthetic joint infection and heterotopic ossification after total hip arthroplasty: systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Heterotopic ossification following COVID-19 infections: systematic literature review of case reports and case series.BMC musculoskeletal disorders · 2024Pooled it
- The significance of heterotopic ossification following total ankle arthroplasty: a systematic review and meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Impact of heterotopic ossification following lumbar total disk replacement: a systematic review.BMC musculoskeletal disorders · 2022Pooled it
- Myositis Ossificans Affecting the Rotator Cuff Muscles and Proximal Humerus: A Rare Clinical Entity.Journal of orthopaedic case reports · 2026Article
- Heterotopic ossifications following an anterior approach total ankle arthroplasty: incidence, distribution, and correlation with rehabilitation.Musculoskeletal surgery · 2026Article
- The alpha and the omega (6 lipids): discovering dietary drivers of heterotopic ossification.The Journal of clinical investigation · 2026Article
- Dietary omega-6 lipids promote postinjury aberrant bone formation in obesity.The Journal of clinical investigation · 2026Article
- Extensive Post-Traumatic Heterotopic Ossification with Multi-joint Involvement: A Case Report.Journal of orthopaedic case reports · 2026Article
- Pelvic heterotopic ossification causing bladder compression: a rare post-traumatic case report.International journal of surgery case reports · 2026Article
- Salivary duct carcinoma with heterotopic ossification in the parotid gland: A case report.Oncology letters · 2026Article
- The prevention of heterotopic ossification around the knee: a scoping review.BMC musculoskeletal disorders · 2026Article
- Heterotopic Ossification in Complete Adductor Longus Tears: A Retrospective Analysis of Associated Factors and Surgical Outcomes.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Reconstruction with muscle flaps after hip joint heterotopic ossification resection in spinal cord injured patients: a case series.Spinal cord series and cases · 2026Article
- Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review).International journal of molecular medicine · 2026Review
- Sustained release PLGA microspheres loaded with a bone-affinity Bmp2 enhance fracture healing and mitigate heterotopic ossification.Bioactive materials · 2026Article
- Ceramide-PKCζ signaling axis mediates burn-enhanced ectopic calcification during Achilles tendon healing.Journal of molecular histology · 2026Article
- Atraumatic intraneural heterotopic ossification of the common peroneal nerve: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Bone fragility in a post-intestinal transplant patient with mesenteric heterotopic ossification.JBMR plus · 2026Article
218 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic features of HO, including nongenetic and genetic forms. First, the clinical features, radiographic appearance, histopathologic diagnosis, and current methods of treatment are discussed. Next, current concepts regarding the mechanistic bases for HO are discussed, including the putative cell types responsible for HO formation, the inflammatory milieu and other prerequisite "niche" factors for HO initiation and propagation, and currently available animal models for the study of HO of this common and potentially devastating condition. © 2019 The Authors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.