ArticleCommunications biology2019
Population structure determines the tradeoff between fixation probability and fixation time.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- Mixed updating in structured populations.PLoS computational biology · 2026Article
- Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations.Nature communications · 2026Article
- Temporality modulates the effect of network heterogeneity on cooperation fixation.Nature communications · 2026Article
- The effect of the fitness gradient on fixation probability.Nature communications · 2026Article
- Article
- Promoters of cooperation in evolutionary games.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Maintaining diversity in structured populations.PNAS nexus · 2025Article
- Colonization times in Moran process on graphs.PLoS computational biology · 2025Article
- Density amplifiers of cooperation for spatial games.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Competition for resources can reshape the evolutionary properties of spatial structure.PLoS computational biology · 2024Article
- Fixation times on directed graphs.PLoS computational biology · 2024Article
- Evolutionary graph theory beyond single mutation dynamics: on how network-structured populations cross fitness landscapes.Genetics · 2024Article
- The speed of neutral evolution on graphs.Journal of the Royal Society, Interface · 2024Article
- A theory of evolutionary dynamics on any complex population structure reveals stem cell niche architecture as a spatial suppressor of selection.Nature communications · 2024Article
- Limits on the evolutionary rates of biological traits.Scientific reports · 2024Article
- Evolutionary graph theory beyond pairwise interactions: Higher-order network motifs shape times to fixation in structured populations.PLoS computational biology · 2024Article
- Amplifiers of selection for the Moran process with both Birth-death and death-Birth updating.PLoS computational biology · 2024Article
- Frequent asymmetric migrations suppress natural selection in spatially structured populations.PNAS nexus · 2023Article
- Evolutionary dynamics of mutants that modify population structure.Journal of the Royal Society, Interface · 2023Article
- Self-loops in evolutionary graph theory: Friends or foes?PLoS computational biology · 2023Article
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4 authors.
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Abstract
The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these amplifiers of natural selection typically increase fixation time. Here we study population structures that achieve a tradeoff between fixation probability and time. First, we show that no amplifiers can have an asymptotically lower absorption time than the well-mixed population. Then we design population structures that substantially augment the fixation probability with just a minor increase in fixation time. Finally, we show that those structures enable higher effective rate of evolution than the well-mixed population provided that the rate of generating advantageous mutants is relatively low. Our work sheds light on how population structure affects the rate of evolution. Moreover, our structures could be useful for lab-based, medical, or industrial applications of evolutionary optimization.
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