ArticlePlastic and reconstructive surgery. Global open2019
Recovery of Motor Function after Mixed and Motor Nerve Repair with Processed Nerve Allograft.
Article in Plastic and reconstructive surgery. Global open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Pooled it
- Neurotized DIEP Breast Reconstruction: A Feasibility Report of a Gap Length-Based Algorithm.Plastic and reconstructive surgery. Global open · 2026Article
- Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.Neural regeneration research · 2026Article
- Optimization of the Missouri Osteochondral Preservation System for the storage of peripheral nerve allografts.JPRAS open · 2026Article
- Motor Function in the Setting of Nerve Allografts: Is This the Future of Facial Nerve Reconstruction?Journal of clinical medicine · 2025Review
- Multiligament Knee Injury With Common Peroneal Nerve Rupture: Single-Stage Reconstruction of the Anterior Cruciate Ligament, Posterolateral Corner, and Common Peroneal Nerve Graft.Arthroscopy techniques · 2025Article
- Effect and mechanism of Tetramethylpyrazine in repair of sciatic nerve injury in rats.BMC neuroscience · 2024Article
- Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models.Bioactive materials · 2023Article
- Selective demyelination of a sciatic nerve allograft after SARS-CoV-2 infection - Case report.Heliyon · 2023Article
- Acellular Nerve Allografts in Major Peripheral Nerve Repairs: An Analysis of Cases Presenting With Limited Recovery.Hand (New York, N.Y.) · 2023Article
- Techniques and graft materials for repairing peripheral nerve defects.Frontiers in neurology · 2023Review
- [Use of acellular allogeneic nerve transplants for nerve defects of the hand : Experience from a German hand surgery center].Unfallchirurgie (Heidelberg, Germany) · 2022Review
- Closing the Gap: Bridging Peripheral Sensory Nerve Defects with a Chitosan-Based Conduit a Randomized Prospective Clinical Trial.Journal of personalized medicine · 2022Article
- A Retrospective Case Series of Peripheral Mixed Nerve Reconstruction Failures Using Processed Nerve Allografts.Plastic and reconstructive surgery. Global open · 2021Article
- Clinical Outcomes of Symptomatic Neuroma Resection and Reconstruction with Processed Nerve Allograft.Plastic and reconstructive surgery. Global open · 2021Article
- Gene expression profiles of human adipose-derived mesenchymal stem cells dynamically seeded on clinically available processed nerve allografts and collagen nerve guides.Neural regeneration research · 2021Article
- Kiteboarding Induced Abdominal Wall Pain: Intercostal Neuroma versus Anterior Cutaneous Nerve Entrapment (ACNES).Plastic and reconstructive surgery. Global open · 2021Article
- Immediate allograft reconstruction of the infraorbital nerve following resection of polyostotic fibrous dysplasia lesion.Case reports in plastic surgery & hand surgery · 2021Article
- Post-mastectomy Breast Reconstruction with Autologous Tissue: Current Methods and Techniques.Plastic and reconstructive surgery. Global open · 2021Review
- Peripheral nerve repair throughout the body with processed nerve allografts: Results from a large multicenter study.Microsurgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere trauma often results in the transection of major peripheral nerves. The RANGER Registry is an ongoing observational study on the use and outcomes of processed nerve allografts (PNAs; Avance Nerve Graft, AxoGen, Inc., Alachua, Fla.). Here, we report on motor recovery outcomes for nerve injuries repaired acutely or in a delayed fashion with PNA and comparisons to historical controls in the literature.
methodsThe RANGER database was queried for mixed and motor nerve injuries in the upper extremities, head, and neck area having completed greater than 1 year of follow-up. All subjects with sufficient assessments to evaluate functional outcomes were included. Meaningful recovery was defined as ≥M3 on the Medical Research Council scale. Demographics, outcomes, and covariate analysis were performed to further characterize this subgroup.
resultsThe subgroup included 20 subjects with 22 nerve repairs. The mean ± SD (minimum-maximum) age was 38 ± 19 (16-77) years. The median repair time was 9 (0-133) days. The mean graft length was 33 ± 17 (10-70) mm with a mean follow-up of 779 ± 480 (371-2,423) days. Meaningful motor recovery was observed in 73%. Subgroup analysis showed no differences between gap lengths or mechanism of injury. There were no related adverse events.
conclusionsPNAs were safe and provided functional motor recovery in mixed and motor nerve repairs. Outcomes compare favorably to historical controls for nerve autograft and exceed those for hollow tube conduit. PNA may be considered as an option when reconstructing major peripheral nerve injuries.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.