Evidence map›Paper›PMID 31044004›Full record

ArticleBiotechnology for biofuels2019

Removal of aromatic inhibitors produced from lignocellulosic hydrolysates by

Anita Singh, Stacy R Bedore, Nilesh K Sharma, Sarah A Lee, Mark A Eiteman, Ellen L Neidle

Open access · goldAbstract read
In one paragraph

Article in Biotechnology for biofuels, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  5. UpgradingACS omega · 2025
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  8. Regulation of tricarboxylate transport and metabolism inApplied and environmental microbiology · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. A LignocellulolyticJournal of fungi (Basel, Switzerland) · 2021
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Anita Singh1Department of Environmental Sciences, Central University of Jammu, Rahya-Suchani, Bagla, India.
Stacy R Bedore3Department of Microbiology, University of Georgia, Athens, GA 30602 USA.
Nilesh K Sharma2School of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602 USA.
Sarah A Lee2School of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602 USA.
Mark A Eiteman1Department of Environmental Sciences, Central University of Jammu, Rahya-Suchani, Bagla, India.ORCID 0000-0002-6155-6446
Ellen L Neidle3Department of Microbiology, University of Georgia, Athens, GA 30602 USA.
University of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLignocellulosic biomass is an attractive, inexpensive source of potentially fermentable sugars. However, hydrolysis of lignocellulose results in a complex mixture containing microbial inhibitors at variable composition. A single microbial species is unable to detoxify or even tolerate these non-sugar components while converting the sugar mixtures effectively to a product of interest. Often multiple substrates are metabolized sequentially because of microbial regulatory mechanisms. To overcome these problems, we engineered strains of

resultsThe two engineered strains, one unable to metabolize benzoate and another unable to metabolize 4-hydroxybenzoate, when grown together removed these two inhibitors simultaneously under batch conditions. Under continuous conditions, a single strain with a deletion in the

conclusionsWe demonstrated approaches for the simultaneous removal of two aromatic inhibitors from a simulated lignocellulosic hydrolysate. A two-stage batch process converted the residual sugar into a non-growth-associated product, ethanol. Such a two-stage process with bacteria (

Indexed as

Acinetobacter baylyiDetoxificationEthanolKluyveromyces marxianusMicrobial consortium

Identifiers

PMID31044004
PMCPMC6477725
OpenAlexW2946577447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.