Evidence map›Paper›PMID 31043758›Full record

SynthesisNature genetics2019

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

Nicole M Warrington, Robin N Beaumont, Momoko Horikoshi, Felix R Day, Øyvind Helgeland, Charles Laurin, Jonas Bacelis, Shouneng Peng, Ke Hao, Bjarke Feenstra and 199 more

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05166447 (Twenty-year Follow-up of the Inter99 Cohort), which is not on this map. Cited by 334 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
334citing papers in PubMed, 13 pooled it
121.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05166447 enrolling by invitationnot on this mapstarted 2021, after this paper: background citation

Twenty-year Follow-up of the Inter99 Cohort

TypeobservationalSponsorBispebjerg HospitalRan2021 to 2028Enrolled4,000ConditionsCoronary Heart Disease, Acute Myocardial Infarction, Cardiovascular Diseases, Type 2 Diabetes
3 · Its place in the literature

Who cites it

334 citing papers in PubMed, 13 syntheses or guidelines pooled it, 631 citations in OpenAlex.

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274 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

209 authors at 20 institutions in 21 countries.

Nicole M WarringtonUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4195-775X
Robin N BeaumontInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.ORCID http://orcid.org/0000-0003-0750-8248
Momoko HorikoshiRIKEN Centre for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Diseases, Yokohama, Japan.
Felix R DayMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0003-3789-7651
Øyvind HelgelandKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0002-5612-2985
Charles LaurinMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-2439-9004
Jonas BacelisDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-2450-732X
Shouneng PengDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ke HaoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-1478-649X
Andrew R WoodInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5585-3420
Jessica TyrrellInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Neil R RobertsonWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
N William RaynerWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Zhen QiaoUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Gunn-Helen MoenDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-8768-0904
Marc VaudelKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Carmen J MarsitDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jia ChenDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael NodzenskiDepartment of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Theresia M SchnurrNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-6573-4959
Mohammad H ZafarmandDepartment of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Jonathan P BradfieldCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5526-1070
Marjolein N KooijmanThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Ruifang Li-GaoDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.
Tarunveer S AhluwaliaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lavinia PaternosterMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-2514-0889
Rico RueediDepartment of Computational Biology, University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6713-2214
Ville HuikariCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Alana CavadinoSection of Epidemiology and Biostatistics, School of Population Health, University of Auckland, Auckland, New Zealand.
Sarah MetrustryDepartment of Twin Research, King's College London, St. Thomas' Hospital, London, UK.ORCID http://orcid.org/0000-0003-2028-7486
Diana L CousminerDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.
Carol A WangSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4301-3974
Christian T HaveNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Natalia Vilor-TejedorCenter for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
Peter K JoshiUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
Jodie N PainterQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia.
Ioanna NtallaWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ronny MyhreDepartment of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0001-7383-4987
Elisabeth M van LeeuwenDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Raimo JoroInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Vasiliki LagouWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Rebecca C RichmondMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0574-5071
Ana EspinosaISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Sheila J BartonMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Hazel M InskipMedical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-8897-1749
John W HollowayHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID http://orcid.org/0000-0001-9998-0464
Loreto Santa-MarinaCIBER de Epidemiología y Salud Pública, Madrid, Spain.
Xavier EstivillSidra Medicine Research Department, Sidra Medicine, Doha, Qatar.ORCID http://orcid.org/0000-0002-0723-2256
Wei AngDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.
Julie A MarshDivision of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.
Christoph ReichetzederInstitute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
Letizia MarulloDepartment of Life Sciences and Biotechnology, Genetic Section, University of Ferrara, Ferrara, Italy.
Berthold HocherFifth Department of Medicine, University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8143-0579
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9268-810X
Joanne M MurabitoFramingham Heart Study, Framingham, MA, USA.
Caroline L ReltonMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Manolis KogevinasISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Leda ChatziDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Catherine AllardCentre de recherche, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID http://orcid.org/0000-0002-8829-4984
Luigi BouchardCentre de recherche, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
Marie-France HivertDepartment of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA, USA.
Ge ZhangHuman Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Louis J MugliaHuman Genetics Division, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-0301-8770
Jani HeikkinenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
EGG Consortium
Camilla S MorgenDepartment of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Antoine H C van KampenBioinformatics Laboratory, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1025-7232
Barbera D C van SchaikBioinformatics Laboratory, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-5568-8127
Frank D MentchCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0002-5017-7344
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Gibran HemaniMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0920-1055
Susan M RingMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Amanda J BennettOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Kyle J GaultonWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1318-7161
Juan Fernandez-TajesWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Natalie R van ZuydamWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Carolina Medina-GomezThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7999-5538
Hugoline G de HaanDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Zoltán KutalikSwiss Institute of Bioinformatics, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8285-7523
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-4548-8500
Shikta DasMedical Research Council Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Sciences, University College London, London, UK.
Gonneke WillemsenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Hamdi MbarekDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-1108-0371
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3793-5910
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.
Emil V R AppelNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7704-6611
Cilius E FonvigNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5031-0125
Caecilie TrierNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Catharina E M van BeijsterveldtNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Mario MurciaCIBER de Epidemiología y Salud Pública, Madrid, Spain.
Mariona BustamanteISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Sílvia Bonas-GuarchJoint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.
David M HougaardDanish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5928-3517
Josep M MercaderJoint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.ORCID http://orcid.org/0000-0001-8494-3660
Allan LinnebergDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-0994-0184
Katharina E SchrautUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Penelope A LindQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-3887-2598
Sarah E MedlandQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Beverley M ShieldsNIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health and Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Bridget A KnightNIHR Exeter Clinical Research Facility, University of Exeter College of Medicine and Health and Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
Jin-Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Kalliope PanoutsopoulouWellcome Sanger Institute, Hinxton, UK.
Meike BartelsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9667-7555
Friman SánchezJoint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.
Jakob StokholmCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4989-9769
David TorrentsJoint BSC-CGR-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain.
Rebecca K VindingCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Sara M WillemsDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Mustafa AtalayInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Bo L ChawesCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6846-6243
Peter KovacsIFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0290-5423
Inga ProkopenkoWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1624-7457
Marcus A TukeInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.ORCID http://orcid.org/0000-0003-0008-9263
Hanieh YaghootkarInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Katherine S RuthInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.ORCID http://orcid.org/0000-0003-4966-9170
Samuel E JonesInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.ORCID http://orcid.org/0000-0003-0153-922X
Po-Ru LohProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Anna MurrayInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Michael N WeedonInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Anke TönjesMedical Department, University of Leipzig, Leipzig, Germany.
Michael StumvollIFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Kim F MichaelsenDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Aino-Maija ElorantaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Wieland KiessPediatric Research Center, Department of Women's andChild Health, University of Leipzig, Leipzig, Germany.
Antje KörnerIFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Harri NiinikoskiDepartment of Pediatrics, Turku University Hospital, Turku, Finland.
Katja PahkalaResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Bo JacobssonDepartment of Genetics and Bioinformatics, Domain of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
Eleftheria ZegginiWellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4238-659X
George V DedoussisDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Yik-Ying TeoSaw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Seang-Mei SawSaw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Queensland, Australia.
Harry CampbellUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
James F WilsonUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Tanja G M VrijkotteDepartment of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3641-4048
Martine VrijheidISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Eco J C N de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6022-2666
M Geoffrey HayesDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Haja N KadarmideenQuantitative and Systems Genomics Group, Department of Bio and Health Informatics, Technical University of Denmark, Lyngby, Denmark.ORCID http://orcid.org/0000-0001-6294-382X
Jens-Christian HolmNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lawrence J BeilinSchool of Medicine, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia.
Craig E PennellSchool of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, New South Wales, Australia.
Joachim HeinrichInstitute of Epidemiology, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.
Linda S AdairDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, USA.
Judith B BorjaUSC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6721-153X
Johan G ErikssonNational Institute for Health and Welfare, Helsinki, Finland.
Elisabeth E WidénInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Andrew T HattersleyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Tim D SpectorDepartment of Twin Research, King's College London, St. Thomas' Hospital, London, UK.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Jorma S ViikariDivision of Medicine, Turku University Hospital, Turku, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Sylvain SebertCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Thorkild I A SørensenMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-4821-430X
Hans BisgaardCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4131-7592
Klaus BønnelykkeCopenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-2003-1018
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8264-6785
Ellen A NohrResearch Unit for Gynaecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Fernando RivadeneiraThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9801-5774
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Charlotta PisingerResearch Center for Prevention and Health, Center for Sundhed, Rigshospitalet Glostrup, Copenhagen University, Glostrup, Denmark.
Allan A VaagDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
André G UitterlindenThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Marjo-Riitta JärvelinCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Christine PowerPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Elina HyppönenPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0003-3670-9399
Denise M ScholtensDepartment of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
William L LoweDepartment of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
George Davey SmithMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Nicholas J TimpsonMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Andrew P MorrisWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6805-6014
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2814-7461
Struan F A GrantCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2025-5302
Timothy M FraylingInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
Debbie A LawlorMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Pål R NjølstadKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
Stefan JohanssonKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Ken K OngMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0003-4689-7530
Mark I McCarthyWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4393-0510
John R B PerryMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
David M EvansUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia. d.evans1@uq.edu.au.ORCID http://orcid.org/0000-0003-0663-4621
Rachel M FreathyInstitute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK. r.freathy@ex.ac.uk.ORCID http://orcid.org/0000-0003-4152-2238
University of Copenhagen · DKUniversity of Exeter · GBCentre for Human Genetics · GBErasmus MC · NLUniversity of Bristol · GBUniversity of Cambridge · GBGGD Amsterdam · NLChildren's Hospital of Philadelphia · USUniversity of Turku · FIAmsterdam UMC Location University of Amsterdam · NLLeiden University Medical Center · NLNorthwestern University · USQIMR Berghofer Medical Research Institute · AUStatens Serum Institut · DKUniversitat Pompeu Fabra · ESUniversity of Eastern Finland · FIHelmholtz Zentrum München · DEIcahn School of Medicine at Mount Sinai · USIFB Adiposity Diseases · DENational University of Singapore · SG

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Environment, Imprinting, and NeurodevelopmentR01ES022223 · NIEHS · EMORY UNIVERSITY · PI CHEN, JIA, MARSIT, CARMEN JOSEPH · 2013 to 2017
$4.3M
Placental Functional Networks Linking Developmental Pesticide Exposure and Offspring NeurodevelopmentR01ES029212 · NIEHS · EMORY UNIVERSITY · PI CAUDLE, WILLIAM MICHAEL, CHEN, JIA · 2018 to 2022
$2.7M
Enriching the Rhode Island Child Health StudyR24ES028507 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit, LAURA R STROUD · 2017 to 2026
$2.3M
Metabolomic and Epigenomic Mechanisms in Developmental Overnutrition.R01DK103246 · NIDDK · UNIVERSITY OF BRISTOL · PI LAWLOR, DEBORAH ANNE · 2014 to 2018
$2.2M
Environmental influences and function of cytosine modification in human placentaR21ES028226 · NIEHS · EMORY UNIVERSITY · PI MARSIT, CARMEN JOSEPH · 2017 to 2018
$429k
Diabetes UK 17/0005594European Research Council 323195Medical Research Council G0601261Medical Research Council G1001357Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2Medical Research Council MR/J012165/1Medical Research Council MR/M005070/1NIDDK NIH HHS R01 DK103246NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES019776NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES022223NIEHS NIH HHS R01 ES029212NIEHS NIH HHS R21 ES028226NIEHS NIH HHS R24 ES028507Wellcome Trust 088806Wellcome Trust 098381Wellcome Trust 098395Wellcome Trust 104150Wellcome Trust 202802Wellcome Trust 202802/Z/16/ZWellcome Trust 205915Wellcome Trust 208806/Z/17/ZWellcome Trust 212259
6 · The paper itself

Abstract

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.

Indexed as

AdultBirth WeightBlood PressureBody HeightDiabetes Mellitus, Type 2FemaleFetal DevelopmentGenetic Predisposition to DiseaseGenome-Wide Association StudyHeart DiseasesHumansInfant, NewbornMaleMaternal-Fetal ExchangeMaternal InheritanceMetabolic Diseases

Identifiers

PMID31043758
PMCPMC6522365
OpenAlexW2896958236

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.