SynthesisNature genetics2019
Genome-wide association study identifies 30 loci associated with bipolar disorder.
Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07173842 (Establishment of the NeuroPsyBiT-BD Omics Program), which is not on this map. Cited by 830 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
830citing papers in PubMed, 7 pooled it
189.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishment of the NeuroPsyBiT-BD Omics Program: Development of a Turkish Bipolar Disorder Biobank Integrating Genomic and Epigenomic Profiling With Structured Clinical Phenotyping and Secure Data Infrastructure
Who cites it
830 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,607 citations in OpenAlex.
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- Epigenetics of bipolar disorder: a bibliometric landscape and visualization analysis.Frontiers in psychiatry · 2026Pooled it
- Increased somatic mosaicism in autosomal and X chromosomes for suicide death.Molecular psychiatry · 2025Pooled it
- Pooled it
- Causal Association Between Sedentary Behaviors and Health Outcomes: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.Nature human behaviour · 2024Pooled it
- Subset-based method for cross-tissue transcriptome-wide association studies improves power and interpretability.HGG advances · 2024Pooled it
- Association of major depression, schizophrenia and bipolar disorder with thyroid cancer: a bidirectional two-sample mendelian randomized study.BMC psychiatry · 2024Trial
- Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Surveying alternative transcripts of disease-associated genes and their cell type specificity - a case study with ANK3.Translational psychiatry · 2026Article
- Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Genetic interconnections between personality-related phenotypes and psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Common alleles associated with connectivity within and across the brain's main functional networks.Nature communications · 2026Article
- SemanticST: A Scalable Multi-Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi-Sample Integration in Spatial Transcriptomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genomic dimensions deconstruct the clinical heterogeneity of bipolar disorder.Research square · 2026Article
- Integrated proteomic, transcriptomic, and epigenomic profiling identifies SRA1 as a novel therapeutic target for postpartum depression.Npj mental health research · 2026Article
- Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Causal association between cataract and psychiatric disorders: A bidirectional 2-sample Mendelian randomization study.Medicine · 2026Article
- Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.Molecular psychiatry · 2026Article
770 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
280 authors at 20 institutions in 21 countries.
Eli A StahlDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eli.stahl@mssm.edu.ORCID http://orcid.org/0000-0002-1192-0561
Gerome BreenMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2053-1792
Andreas J ForstnerDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Andrew McQuillinDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0003-1567-2240
Stephan RipkeStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Vassily TrubetskoyDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
Manuel MattheiseniSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Yunpeng WangInstitute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen, Denmark.
Jonathan R I ColemanMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Héléna A GasparMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Christiaan A de LeeuwDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Stacy SteinbergdeCODE Genetics/Amgen, Reykjavik, Iceland.
Jennifer M Whitehead PavlidesQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Maciej TrzaskowskiInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Enda M ByrneInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Tune H PersMedical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Peter A HolmansMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Alexander L RichardsMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Liam AbbottStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Esben AgerboiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Huda AkilMolecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Diego AlbaniDepartment of Neuroscience, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Ney Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Thomas D AlsiSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Adebayo AnjorinDepartment of Psychiatry, Berkshire Healthcare NHS Foundation Trust, Bracknell, UK.
Verneri AntillaAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Swapnil AwasthiDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
Judith A BadnerDepartment of Psychiatry, Rush University Medical Center, Chicago, IL, USA.
Marie Bækvad-HanseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Jack D BarchasDepartment of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Nicholas BassDivision of Psychiatry, University College London, London, UK.
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Richard BelliveauStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Sarah E BergenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Carsten Bøcker PederseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Erlend BøenDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Marco P BoksPsychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.
James BoocockHuman Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
William BunneyDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Margit BurmeisterMolecular & Behavioral Neuroscience Institute and Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Jonas Bybjerg-GrauholmiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
William ByerleyDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Miquel CasasInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Felecia CerratoStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Pablo CervantesDepartment of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Quebec, Canada.
Kimberly ChambertStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Alexander W CharneyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Danfeng ChenStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Claire ChurchhouseStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Toni-Kim ClarkeDivision of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
William CoryellUniversity of Iowa Hospitals and Clinics, Iowa City, IA, USA.
David W CraigTranslational Genomics, USC, Phoenix, AZ, USA.
Cristiana CruceanuDepartment of Psychiatry, Mood Disorders Program, McGill University Health Center, Montreal, Quebec, Canada.
David CurtisCentre for Psychiatry, Queen Mary University of London, London, UK.
Piotr M CzerskiDepartment of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
Anders M DaleDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Simone de JongMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Jurgen Del-FaveroApplied Molecular Genomics Unit, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway.
Amanda L DobbynDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ashley DumontStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Torbjørn ElvsåshagenDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Valentina Escott-PriceMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Chun Chieh FanDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.
Sascha B FischerDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Matthew FlickingerCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Tatiana M ForoudDepartment of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Liz FortyMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Josef FrankDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christine FraserMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Nelson B FreimerCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Louise FrisénDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Katrin GadeInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Diane GageStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Julie GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Claudia GiambartolomeiDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Marianne Giørtz PederseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Jaqueline GoldsteinStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Scott D GordonGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Katherine Gordon-SmithDepartment of Psychological Medicine, University of Worcester, Worcester, UK.
Elaine K GreenSchool of Biomedical Sciences, Plymouth University Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK.
Melissa J GreenSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Tiffany A GreenwoodDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Jakob GroveiSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Weihua GuanBiostatistics, University of Minnesota System, Minneapolis, MN, USA.
José Guzman-ParraMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Marian L HamshereMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Martin HautzingerDepartment of Psychology, Eberhard Karls Universität Tübingen, Tubingen, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Stefan HermsDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Maria HipolitoDepartment of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Per HoffmannDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Dominic HollandDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Laura HuckinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stéphane JamainPsychiatrie Translationnelle, Inserm U955, Créteil, France.
Jessica S JohnsonDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anders JuréusDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Radhika KandaswamyMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
James L KennedyCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Onatario, Canada.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
James A KnowlesCell Biology, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Manolis KogevinasISGlobal, Barcelona, Spain.
Anna C KollerInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Ralph KupkaPsychiatry, Altrecht, Utrecht, the Netherlands.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Jacob LawrenceDepartment of, rth East London NHS Foundation Trust, Ilford, UK.
William B LawsonDepartment of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Markus LeberDepartment of Neurodegenerative Diseases and Geropsychiatry, University Hospital Bonn, Bonn, Germany.
Phil H LeeStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Shawn E LevyHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
Chunyu LiuDepartment of Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
Susanne LucaeMax Planck Institute of Psychiatry, Munich, Germany.
Anna MaaserInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Donald J MacIntyreMental Health, NHS 24, Glasgow, UK.
Pamela B MahonDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wolfgang MaierDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Lina MartinssonDepartment of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Steve McCarrollStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Peter McGuffinMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
James D McKayGenetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Helena MedeirosInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Sarah E MedlandGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Fan MengMolecular & Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu, Estonia.
Grant W MontgomeryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Derek W MorrisDiscipline of Biochemistry, Neuroimaging and Cognitive Genomics (NICOG) Centre, National University of Ireland, Galway, Galway, Ireland.
Thomas W MühleisenDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Niamh MullinsMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Hoang NguyenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Caroline M NievergeltDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Annelie Nordin AdolfssonDepartment of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Evaristus A NwuliaDepartment of Psychiatry and Behavioral Sciences, Howard University Hospital, Washington, DC, USA.
Claire O'DonovanDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Loes M Olde LoohuisCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Anil P S OriCenter for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Lilijana OrucDepartment of Clinical Psychiatry, Psychiatry Clinic, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Urban ÖsbyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Roy H PerlisDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Amy PerryDepartment of Psychological Medicine, University of Worcester, Worcester, UK.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shaun M PurcellDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eline J RegeerOutpatient Clinic for Bipolar Disorder, Altrecht, Utrecht, the Netherlands.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
Céline S ReinboldDepartment of Biomedicine, University of Basel, Basel, Switzerland.
John P RiceDepartment of Psychiatry, Washington University in Saint Louis, Saint Louis, MO, USA.
Fabio RivasMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Margarita RiveraMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Panos RoussosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Douglas M RuderferMedicine, Psychiatry, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Euijung RyuDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Cristina Sánchez-MoraInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Alan F SchatzbergPsychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
William A ScheftnerRush University Medical Center, Chicago, IL, USA.
Nicholas J SchorkScripps Translational Science Institute, La Jolla, CA, USA.
Cynthia Shannon WeickertSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Tatyana ShehktmanDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Paul D ShillingDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Engilbert SigurdssonFaculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Claire SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Olav B SmelandDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Janet L SobellPsychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, CA, USA.
Christine Søholm HanseniPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Anne T SpijkerMood Disorders, PsyQ, Rotterdam, the Netherlands.
David St ClairInstitute for Medical Sciences, University of Aberdeen, Aberdeen, UK.
Michael SteffensResearch Division, Federal Institute for Drugs and Medical Devices (BfArM), Bonn, Germany.
John S StraussDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jana StrohmaierDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Szabolcs SzelingerNeurogenomics, TGen, Phoenix, AZ, USA.
Robert C ThompsonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Thorgeir E ThorgeirssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Jens TreutleinDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Helmut VedderDepartment of Psychiatry, Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
Weiqing WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stanley J WatsonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Thomas W WeickertSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Simon XiComputational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA.
Wei XuDepartment of Biostatistics, Princess Margaret Cancer Centre, Toronto, Onatario, Canada.
Allan H YoungPsychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Peter ZandiDepartment of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Peng ZhangInstitute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sebastian ZöllnerDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
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Rolf AdolfssonDepartment of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.
Ingrid AgartzDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Lena BacklundDepartment of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Bernhard T BauneDepartment of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
Frank BellivierDepartment of Psychiatry and Addiction Medicine, Assistance Publique-Hopitaux de Paris, Paris, France.
Wade H BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Joanna M BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Douglas H R BlackwoodDivision of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
Michael BoehnkeCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Anders D BørglumiSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Aiden CorvinNeuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Nicholas CraddockMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Mark J DalyStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Udo DannlowskiDepartment of Psychiatry, University of Munster, Munster, Germany.
Tõnu EskoMedical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Bruno EtainDepartment of Psychiatry and Addiction Medicine, Assistance Publique-Hopitaux de Paris, Paris, France.
Mark FryeDepartment of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales, Australia.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Michael GillNeuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
Fernando GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
Joanna HauserDepartment of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
David M HougaardiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Christina M HultmanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Ian JonesMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Lisa A JonesDepartment of Psychological Medicine, University of Worcester, Worcester, UK.
René S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
George KirovMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Marion LeboyerFaculté de Médecine, Université Paris Est, Créteil, France.
Cathryn M LewisMRC Social, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.
Qingqin S LiNeuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA.
Jolanta LissowskaCancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
Nicholas G MartinGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Fermin MayoralMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Susan L McElroyResearch Institute, Lindner Center of HOPE, Mason, OH, USA.
Andrew M McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, Scotland.
Francis J McMahonHuman Genetics Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Ingrid MelleDivision of Mental Health and Addiction and Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Philip B MitchellSchool of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Gunnar MorkenMental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology-NTNU, Trondheim, Norway.
Ole MorsiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Preben Bo MortenseniSEQ, Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.
Bertram Müller-MyhsokDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Benjamin M NealeMedical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Vishwajit NimgaonkarPsychiatry and Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Merete NordentoftiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
Markus M NöthenInstitute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
Michael C O'DonovanMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Ketil J OedegaardDivision of Psychiatry, Haukeland Universitetssjukehus, Bergen, Norway.
Michael J OwenMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Sara A PacigaHuman Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA.
Carlos PatoInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Michele T PatoInstitute for Genomic Health, SUNY Downstate Medical Center College of Medicine, Brooklyn, NY, USA.
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Josep Antoni Ramos-QuirogaInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Marta RibasésInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Guy A RouleauDepartment of Neurology and Neurosurgery, McGill University, Faculty of Medicine, Montreal, Quebec, Canada.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Peter R SchofieldNeuroscience Research Australia, Sydney, New South Wales, Australia.
Thomas G SchulzeInstitute of Psychiatric Phenomics and Genomics, University Hospital, LMU Munich, Munich, Germany.
Alessandro SerrettiDepartment of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Jordan W SmollerStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Hreinn StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Eystein StordalDepartment of Psychiatry, Hospital Namsos, Namsos, Norway.
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gustavo TureckiDepartment of Psychiatry, McGill University, Montreal, Quebec, Canada.
Arne E VaalerDepartment of Psychiatry, Sankt Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Norway.
Eduard VietaClinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
John B VincentCentre for Addiction and Mental Health, Toronto, Onatario, Canada.
Thomas WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.
John I NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Naomi R WrayQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Arianna Di FlorioMedical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, England.
Howard J EdenbergBiochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Sven CichonDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Roel A OphoffPsychiatry, UMC Utrecht Brain Center Rudolf Magnus, Utrecht, the Netherlands.
Laura J ScottCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Ole A AndreassenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
John KelsoeDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA. jkelsoe@ucsd.edu.ORCID http://orcid.org/0000-0002-3013-2333
Pamela SklarDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Broad Institute · USCardiff University · GBUniversity of Michigan · USKing's College London · GBUniversity of Bonn · DEAarhus University · DKUniversity of California San Diego · USIcahn School of Medicine at Mount Sinai · USJohns Hopkins University · USHeidelberg University · DEKarolinska University Hospital · SEThe University of Queensland · AUUniversity of California, Los Angeles · USUNSW Sydney · AUKarolinska Institutet · SEOslo University Hospital · NODalhousie University · CAdeCODE Genetics (Iceland) · ISInserm · FRStatens Serum Institut · DK
Funding
African Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7MGenomic Psychiatry CohortR01MH085548 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PATO, CARLOS N, PATO, MICHELE T · 2008 to 2012
$16.3MLatino Ancestry Genomic Psychiatry CohortR01MH123451 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2020 to 2025
$7.1M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9M3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7MComprehensive analysis of genetic pleiotropy in eleven neuropsychiatric disordersR01MH119243 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, PHIL H. · 2020 to 2024
$2.3MNeuroimaging genetics to study social cognitive deficits in ASD and schizophreniaR00MH101367 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, PHIL H. · 2017 to 2019
$747kMedical Research Council G1000708Medical Research Council MR/L010305/1Medical Research Council MR/L023784/2NIMH NIH HHS R00 MH101367NIMH NIH HHS R01 MH085548NIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH119243NIMH NIH HHS R01 MH123451NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109536Wellcome TrustWorld Health Organization 001
Abstract
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10
Indexed as
Genetic LociBipolar DisorderCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMajor Depressive DisorderMalePolymorphism, Single NucleotidePsychotic DisordersSchizophreniaSystems Biology
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NCT07173842ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.