ArticleScientific reports2019
Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Relationship of temperature with declines and persistence of Myotis lucifugus after white-nose syndrome.Conservation biology : the journal of the Society for Conservation Biology · 2026Article
- From protection to amplification: Imperfect chytridiomycosis prophylaxis increases infections in wild amphibians.bioRxiv : the preprint server for biology · 2026Article
- Occupancy and activity patterns of a newly white-nose syndrome infected species in Texas, the Tricolored Bat (Journal of mammalogy · 2026Article
- Mechanisms of volatile organic compounds from bat cave environments againstApplied and environmental microbiology · 2025Article
- Differential Population Responses to White-Nose Syndrome Between Two Michigan Bat Hibernacula Are Not due to Differences in Host Susceptibility.Ecology and evolution · 2025Article
- Low-Coverage Whole-Genome Analysis of Population Structure, Bottlenecks, and Selection in Indiana Bats Before and After White-Nose Syndrome.Molecular ecology · 2025Article
- Article
- A novel method for estimating pathogen presence, prevalence, load, and dynamics at multiple scales.Scientific reports · 2025Article
- Fungal impacts on Earth's ecosystems.Nature · 2025Review
- Strategies and limitations of the bat immune response toFrontiers in immunology · 2025Review
- The state of the bats in North America.Annals of the New York Academy of Sciences · 2024Article
- What are the 100 most cited fungal genera?Studies in mycology · 2024Article
- Advances in understanding bat infection dynamics across biological scales.Proceedings. Biological sciences · 2024Review
- Infection of bats with Histoplasma species.Medical mycology · 2023Review
- Selection of an anti-pathogen skin microbiome following prophylaxis treatment in an amphibian model system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Immunogenicity of poxvirus-based vaccines against Nipah virus.Scientific reports · 2023Article
- The WHO fungal priority pathogens list as a game-changer.Nature reviews. Microbiology · 2023Article
- Safety and immunogenicity of orally administered poxvirus vectored constructs in the white-footed mouse (Vaccine: X · 2023Article
- Inferring the disruption of rabies circulation in vampire bat populations using a betaherpesvirus-vectored transmissible vaccine.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era.International health · 2023Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American hibernating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS vaccine candidates in wild-caught Myotis lucifugus. In a pilot study, we immunized bats with one of four vaccine treatments or phosphate-buffered saline (PBS) as a control and challenged them with Pd upon transfer into hibernation chambers. Bats in one vaccine-treated group, that received raccoon poxviruses (RCN) expressing Pd calnexin (CAL) and serine protease (SP), developed WNS at a lower rate (1/10) than other treatments combined (14/23), although samples sizes were small. The results of a second similar trial provided additional support for this observation. Bats vaccinated orally or by injection with RCN-CAL and RCN-SP survived Pd challenge at a significantly higher rate (P = 0.01) than controls. Using RT-PCR and flow cytometry, combined with fluorescent in situ hybridization, we determined that expression of IFN-γ transcripts and the number of CD4 + T-helper cells transcribing this gene were elevated (P < 0.10) in stimulated lymphocytes from surviving vaccinees (n = 15) compared to controls (n = 3). We conclude that vaccination with virally-vectored Pd antigens induced antifungal immunity that could potentially protect bats against WNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.