Evidence map›Paper›PMID 31043532›Full record

Observational studyJournal of virology2019

Expansion of Stem Cell-Like CD4

Jernej Pušnik, Michael A Eller, Boonrat Tassaneetrithep, Bruce T Schultz, Leigh Anne Eller, Sorachai Nitayaphan, Josphat Kosgei, Lucas Maganga, Hannah Kibuuka, Galit Alter and 3 more

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Protein-dependent CD4iScience · 2026
    Article
  2. Maintenance of intestinal CX3CR1Nature communications · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Preferential and persistent impact of acute HIV-1 infection on CD4Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Observational
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Jernej PušnikInstitute for HIV-1 Research, University Hospital, University Duisburg-Essen, Essen, Germany.
Michael A EllerU.S. Military HIV-1 Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Boonrat TassaneetrithepOffice for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Bruce T SchultzInstitute for HIV-1 Research, University Hospital, University Duisburg-Essen, Essen, Germany.
Leigh Anne EllerU.S. Military HIV-1 Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Sorachai NitayaphanDepartment of Retrovirology, U.S. Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Josphat KosgeiKenya Medical Research Institute/Walter Reed Project, Kericho, Kenya.
Lucas MagangaWalter Reed Program-Tanzania, Mbeya, Tanzania.
Hannah KibuukaMakerere University Walter Reed Project, Kampala, Uganda.
Galit AlterMassachusetts General Hospital, Boston, Massachusetts, USA.
Nelson L MichaelU.S. Military HIV-1 Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Merlin L RobbU.S. Military HIV-1 Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Hendrik StreeckInstitute for HIV-1 Research, University Hospital, University Duisburg-Essen, Essen, Germany hendrik.streeck@uk-essen.de.ORCID 0000-0002-0335-6390
Henry M. Jackson Foundation · USUniversity of Duisburg-Essen · DEArmed Forces Research Institute of Medical Science · THKenya Medical Research Institute · KEMakerere University Walter Reed Project · UGMassachusetts General Hospital · USSiriraj Hospital · THWalter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute HIV-1 infection is characterized by high viremia and massive depletion of CD4

Indexed as

Immunologic MemoryAcute DiseaseCD4-Positive T-LymphocytesCohort StudiesFemaleHIV-1HIV InfectionsHumansMaleStem CellsUp-RegulationViremiaacute infectionCD4 T cellFashuman immunodeficiency viruslatent reservoirmemory populationSCM (stem-cell-like memory)

Identifiers

PMID31043532
PMCPMC6600211
OpenAlexW2942622898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.