Evidence map›Paper›PMID 31043421›Full record

ArticleDevelopment (Cambridge, England)2019

Doublesex controls specification and maintenance of the gonad stem cell niches in

Nicole Camara, Cale Whitworth, Abigail Dove, Mark Van Doren

Open access · greenAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Tissue-specific metabolomic signatures for aRoyal Society open science · 2025
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  9. Steroid signaling controls sex-specific development in an invertebrate.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. A genetic switch for male UV iridescence in an incipient species pair of sulphur butterflies.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. The Regulation of Germline Sex Determination in Drosophila by Sex lethal.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nicole CamaraDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Cale WhitworthDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Abigail DoveDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.
Mark Van DorenDepartment of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA vandoren@jhu.edu.ORCID 0000-0002-5475-003X
Johns Hopkins University · USUniversity of Baltimore · US

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Regulation of Sex-Specific Gonad Stem Cell Niche Development by DoublesexR01GM113001 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 2016 to 2023
$3.1M
Sexual development of the Drosophila gonadR01GM084356 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 2009 to 2016
$2.9M
NIGMS NIH HHS R01 GM084356NIGMS NIH HHS R01 GM113001NIGMS NIH HHS T32 GM007231NIH HHS P40 OD018537
6 · The paper itself

Abstract

Sex-specific development of the gonads is a key aspect of sexual dimorphism that is regulated by Doublesex/Mab3-related transcription factors (DMRTs) in diverse animal species. We find that in mutants for

Indexed as

Drosophila melanogasterAnimalsAnimals, Genetically ModifiedDNA-Binding ProteinsDrosophila ProteinsFemaleGonadsMaleOrgan SpecificitySex Determination ProcessesStem Cell NicheTranscription FactorsBric-a-brac protein 1, DrosophilaDNA-Binding ProteinsDrosophila ProteinsDSX protein, DrosophilaTranscription Factorsbric a bracDMRTdoublesexGonadSexual dimorphismStem cell niche

Identifiers

PMID31043421
PMCPMC6589078
OpenAlexW2943005457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.