Evidence map›Paper›PMID 31043415›Full record

ArticleCancer immunology research2019

Endogenous CD4

Joshua R Veatch, Brenda L Jesernig, Julia Kargl, Matthew Fitzgibbon, Sylvia M Lee, Christina Baik, Renato Martins, A McGarry Houghton, Stanley R Riddell

Open access · bronzeAbstract read
In one paragraph

Article in Cancer immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 86 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Shared neoantigens for cancer immunotherapy.Molecular therapy. Oncology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Facts and Hopes in Immunotherapy Strategies Targeting Antigens Derived from KRAS Mutations.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Joshua R VeatchImmunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. jveatch@fhcrc.org.
Brenda L JesernigImmunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Julia KarglImmunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Matthew FitzgibbonImmunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Sylvia M LeeDivision of Medical Oncology, University of Washington, Seattle, Washington.
Christina BaikDivision of Medical Oncology, University of Washington, Seattle, Washington.
Renato MartinsDivision of Medical Oncology, University of Washington, Seattle, Washington.
A McGarry HoughtonImmunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Stanley R RiddellImmunotherapy Integrated Research Center, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Fred Hutch Cancer Center · USUniversity of Washington Medical Center · USMedical University of Graz · AT

Funding

Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkersP50CA228944 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Alice Berger · 2019 to 2026
$19.6M
TRAINING IN CANCER BIOLOGY &TRANSPLANTATIONT32CA009515 · NCI · UNIVERSITY OF WASHINGTON · PI NANCY ELLEN DAVIDSON, Effie W Petersdorf · 1985 to 2026
$16.2M
CAREER DEVELOPMENT IN PEDIATRIC AND MEDICAL ONCOLOGYK12CA076930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DAVIDSON, NANCY ELLEN, MESHINCHI, SOHEIL · 1997 to 2025
$13.1M
TARGETING ROR1 WITH CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLSR01CA114536 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Sylvain Simon · 2005 to 2026
$8.4M
NCI NIH HHS K12 CA076930NCI NIH HHS P50 CA228944NCI NIH HHS R01 CA114536NCI NIH HHS T32 CA009515
6 · The paper itself

Abstract

T cells specific for neoantigens encoded by mutated genes in cancers are increasingly recognized as mediators of tumor destruction after immune-checkpoint inhibitor therapy or adoptive cell transfer. Much of the focus has been on identifying epitopes presented to CD8

Indexed as

MutationAgedAntigens, NeoplasmCarcinoma, Non-Small-Cell LungCD4-Positive T-LymphocytesCell Line, TumorComputational BiologyErb-b2 Receptor Tyrosine KinasesFemaleGene ExpressionHumansLung NeoplasmsLymphocyte ActivationLymphocytes, Tumor-InfiltratingMaleMiddle AgedAntigens, NeoplasmERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesKRAS protein, humanProto-Oncogene Proteins p21(ras)RNA, Messenger

Identifiers

PMID31043415
PMCPMC6584616
OpenAlexW2943013004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.