Evidence map›Paper›PMID 31043179›Full record

ArticleAlzheimer's research & therapy2019

Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease.

Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Bente Finsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Athanasios MetaxasDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløws Vej 25, DK-5000, Odense C, Denmark. ametaxas@health.sdu.dk.ORCID 0000-0002-8747-7068
Marco AnzaloneDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløws Vej 25, DK-5000, Odense C, Denmark.
Ramanan VaitheeswaranDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløws Vej 25, DK-5000, Odense C, Denmark.
Sussanne PetersenDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløws Vej 25, DK-5000, Odense C, Denmark.
Anne M LandauDepartment of Nuclear Medicine & PET Center, Aarhus University and Hospital, Nørrebrogade 44, Building 10G, DK-8000, Aarhus, Denmark.
Bente FinsenDepartment of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløws Vej 25, DK-5000, Odense C, Denmark.
University of Southern Denmark · DKAarhus University · DK

Funding

Fonden til Lægevidenskabens Fremme 15-267Syddansk Universitet SDU2020
6 · The paper itself

Abstract

backgroundDiscrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (SERT) antagonists in Alzheimer's disease.

methodsTo address the discrepancy, we measured the activity and density of SERT in the neocortex of 3-24-month-old APP

resultsDecreased SERT density was observed in the parietal and frontal cortex of 18-24-month-old APP

conclusionsThe progression of cerebral amyloidosis is associated with neuroinflammation and decreased presynaptic markers of serotonergic integrity and activity. The Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsDisease Models, AnimalEncephalitisFemaleMaleMice, Inbred C57BLMice, TransgenicNeocortexPeptide FragmentsSerotonin Plasma Membrane Transport ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-40)Peptide FragmentsSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseAlzheimer’s diseaseAmyloid-betaAPP swe /PS1 dE9CytokinesDASBNeuroinflammationSerotonin transporterSSRIsTSPO

Identifiers

PMID31043179
PMCPMC6495598
OpenAlexW2943280373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.