Evidence map›Paper›PMID 31042580›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2020

Alcohol Rehabilitation Within 30 Days of Hospital Discharge Is Associated With Reduced Readmission, Relapse, and Death in Patients With Alcoholic Hepatitis.

Thoetchai Bee Peeraphatdit, Patrick S Kamath, Victor M Karpyak, Brian Davis, Vivek Desai, Suthat Liangpunsakul, Arun Sanyal, Naga Chalasani, Vijay H Shah, Douglas A Simonetto

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  14. Alcohol use disorder in alcohol-associated liver disease: Two sides of the same coin.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2024
    Article
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  20. [Progress in the clinical treatment of alcoholic hepatitis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
4 · The record

Corrections and comments

  • Commented on by
    2020
5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Thoetchai Bee PeeraphatditDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Patrick S KamathDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Victor M KarpyakDepartment of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Brian DavisDivision of Gastroenterology and Hepatology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Vivek DesaiDepartment of Family Medicine, Institute for Family Health, New York, New York.
Suthat LiangpunsakulDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Roudebush Veterans Administration Medical Center, Indianapolis, Indiana.
Arun SanyalDivision of Gastroenterology and Hepatology, Department of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Naga ChalasaniDivision of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Vijay H ShahDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
Douglas A SimonettoDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota. Electronic address: simonetto.douglas@mayo.edu.
Mayo Clinic · USVirginia Commonwealth University · USIndiana University School of MedicineInstitute for Family Health · USRichard L. Roudebush VA Medical Center · US

Funding

TREAT-MayoU01AA021788 · NIAAA · MAYO CLINIC ROCHESTER · PI MALHI, HARMEET, SHAH, VIJAY H. · 2012 to 2022
$4.7M
Randomized Placebo Controlled Pilot Trial to determine the efficacy of an IL22 agonist (F-652) in patients with Alcoholic HepatitisU01AA026886 · NIAAA · MAYO CLINIC ROCHESTER · PI SHAH, VIJAY H., SIMONETTO, DOUGLAS A. · 2018 to 2022
$375k
NIAAA NIH HHS U01 AA021788NIAAA NIH HHS U01 AA026886
6 · The paper itself

Abstract

BACKGROUND &

aimsPatients admitted to the hospital for alcoholic hepatitis (AH) are at increased risk of readmission and death. We aimed to identify factors associated with readmission, alcohol relapse, and mortality.

methodsWe performed a retrospective analysis of consecutive patients admitted with AH to a tertiary care hospital from 1999 through 2016 (test cohort, n = 135). We validated our findings in a prospective analysis of patients in a multi-center AH research consortium from 2013 through 2017 (validation cohort, n = 159). Alcohol relapse was defined as any amount of alcohol consumption within 30 days after hospital discharge. Early alcohol rehabilitation was defined as residential or outpatient addiction treatment or mutual support group participation within 30 days after hospital discharge.

resultsThirty-day readmission rates were 30% in both cohorts. Alcohol relapse rates were 37% in the test and 34% in the validation cohort. Following hospital discharge, 27 patients (20%) in the test cohort and 19 patients (16%) in the validation cohort attended early alcohol rehabilitation. There were 53 deaths (39%) in a median follow-up time of 2.8 years and 42 deaths (26%) in a median follow-up time of 1.3 years, respectively. In the test cohort, early alcohol rehabilitation reduced odds for 30-day readmission (adjusted odds ratios [AOR] 0.16; 95% CI, 0.04-0.65; P = .01), 30-day alcohol relapse (AOR, 0.11; 95% CI, 0.02-0.53; P < .001), and death (adjusted hazard ratio [AHR], 0.20; 95% CI, 0.05-0.56; P = .001). In the validation cohort early alcohol rehabilitation reduced odds for 30-day readmission (AOR, 0.30; 95% CI, 0.09-0.98; P = .04), 30-day alcohol relapse (AOR 0.09; 95% CI, 0.01-0.73; P = .02), and death (AHR, 0.20; 95% CI, 0.01-0.94; P = .04). A model combining alcohol rehabilitation and bilirubin identified patients with readmission to the hospital within 30 days with an area under the receiver operating characteristic curve of 0.73.

conclusionsIn an analysis from two cohorts of patients admitted with AH, early alcohol rehabilitation can reduce risk of hospital readmission, alcohol relapse, and death and should be considered as a quality indicator in AH hospitalization treatment.

Indexed as

Hepatitis, AlcoholicPatient DischargeHospitalsHumansPatient ReadmissionRecurrenceRetrospective StudiesAddiction TreatmentAlcohol AbstinenceAlcohol Use DisorderChemical Dependency

Identifiers

PMID31042580
PMCPMC9764228
OpenAlexW2942086152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.