Evidence map›Paper›PMID 31042463›Full record

ArticleCell reports2019

APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Carole Deyts, Mary Clutter, Nicholas Pierce, Paramita Chakrabarty, Thomas B Ladd, Anna Goddi, Awilda M Rosario, Pedro Cruz, Kulandaivelu Vetrivel, Steven L Wagner and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
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  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Tip60/Kat5 may be a novel candidate histone acetyltransferase for the regulation of liver iron localization via acetylation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Article
  13. Article
  14. LncRNA NEAT1 promotes Alzheimer's disease by down regulating micro-27a-3p.American journal of translational research · 2021
    Article
  15. The biogenesis and biology of amyloid β oligomers in the brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020
    Review
  16. Article
  17. Amyloid, APP, and Electrical Activity of the Brain.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Carole DeytsDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Mary ClutterDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Nicholas PierceDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Paramita ChakrabartyDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Thomas B LaddDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Anna GoddiDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Awilda M RosarioDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Pedro CruzDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Kulandaivelu VetrivelDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Steven L WagnerDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA; Veterans Affairs San Diego Healthcare System, La Jolla, CA 92161, USA.
Gopal ThinakaranDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Todd E GoldeDepartment of Neuroscience, Center for Translational Research in Neurodegenerative Disease, and McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
Angèle T ParentDepartment of Neurobiology, The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA. Electronic address: aparent@uchicago.edu.
University of Chicago · USUniversity of Florida · USUniversity of California, San Diego · US

Funding

Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, PETERS, METTE · 2013 to 2022
$24.6M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI YACHNIS, ANTHONY · 2015 to 2019
$7.3M
Immune-Mediated Mechanisms Underlying CNS Abeta ClearanceR01AG018454 · NIA · UNIVERSITY OF FLORIDA · PI GOLDE, TODD E · 2000 to 2018
$5.3M
Targeting y-secretase in GVHDP01CA166009 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI OSBORNE, BARBARA A · 2013 to 2017
$4.9M
STRUCTURAL AND FUNCTIONAL ANALYSIS OF PRESENILINSR01AG019070 · NIA · UNIVERSITY OF CHICAGO · PI THINAKARAN, GOPAL · 2001 to 2015
$4.9M
Presenilins and Cell Adhesion MoleculesR01NS055223 · NINDS · UNIVERSITY OF CHICAGO · PI PARENT, ANGELE · 2008 to 2012
$1.7M
Animal models of membrane-targeted APP intracellular domain - Resubmission 01R21AG042762 · NIA · UNIVERSITY OF CHICAGO · PI PARENT, ANGELE · 2013 to 2014
$435k
NCATS NIH HHS UL1 TR000430NCI NIH HHS P01 CA166009NIA NIH HHS P50 AG047266NIA NIH HHS R01 AG018454NIA NIH HHS R01 AG019070NIA NIH HHS R21 AG042762NIA NIH HHS U01 AG046139NINDS NIH HHS R01 NS055223
6 · The paper itself

Abstract

Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer's disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are pathogenic, the APP holoprotein serves multiple purposes in the nervous system through its cell adhesion and receptor-like properties. Our studies focused on the signaling mediated by the APP cytoplasmic tail. We investigated whether sustained APP signaling during brain development might favor neuronal plasticity and memory process through a direct interaction with the heterotrimeric G-protein subunit Gα

Indexed as

MemoryNeurogenesisSignal TransductionAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsBrainCells, CulturedFemaleGTP-Binding Protein alpha Subunits, GsHEK293 CellsHumansMaleMiceMice, Inbred C57BLNeuronal PlasticityAmyloid beta-Protein PrecursorGTP-Binding Protein alpha Subunits, Gsadenylate cyclaseAlzheimer disease mouse modelamyloidosisamyloid precursor proteinAPP C-terminal fragmentAPP processingcognitive functionG-protein signalinglipid raft

Identifiers

PMID31042463
PMCPMC6508668
OpenAlexW2942893595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.