Evidence map›Paper›PMID 31042419›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

Hydrogen peroxide inhibits neurons in the paraventricular nucleus of the hypothalamus via potassium channel activation.

Heather A Dantzler, Michael P Matott, Diana Martinez, David D Kline

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Anti-hypertensive effect of hydrogen peroxide acting centrally.Hypertension research : official journal of the Japanese Society of Hypertension · 2020
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Heather A DantzlerDepartment of Biomedical Sciences, University of Missouri , Columbia, Missouri.
Michael P MatottDepartment of Biomedical Sciences, University of Missouri , Columbia, Missouri.ORCID 0000-0002-7883-4473
Diana MartinezDepartment of Biomedical Sciences, University of Missouri , Columbia, Missouri.ORCID 0000-0003-0982-4092
David D KlineDepartment of Biomedical Sciences, University of Missouri , Columbia, Missouri.ORCID 0000-0003-3269-0184
University of Missouri · US

Funding

Plasticity of nTS Output Neurons In Acute and Chronic HypoxiaR01HL098602 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CUMMINGS, KEVIN JAMES, HASSER, EILEEN M · 2010 to 2023
$8.5M
Neurophysiology and plasticity of cardiorespiratory circuits to hypoxiaR01HL128454 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI KLINE, DAVID DOUGLAS · 2016 to 2019
$2.0M
NHLBI NIH HHS R01 HL098602NHLBI NIH HHS R01 HL128454
6 · The paper itself

Abstract

The paraventricular nucleus (PVN) of the hypothalamus is an important homeostatic and reflex center for neuroendocrine, respiratory, and autonomic regulation, including during hypoxic stressor challenges. Such challenges increase reactive oxygen species (ROS) to modulate synaptic, neuronal, and ion channel activity. Previously, in the nucleus tractus solitarius, another cardiorespiratory nucleus, we showed that the ROS H

Indexed as

AnimalsBarium CompoundsChloridesDiazoxideGlyburideHydrogen PeroxideHypoglycemic AgentsMaleNeuronsParaventricular Hypothalamic NucleusPotassium Channel BlockersPotassium ChannelsRatsRats, Sprague-Dawleybarium chlorideBarium CompoundsChloridesDiazoxideGlyburideHydrogen PeroxideHypoglycemic AgentsPotassium Channel BlockersPotassium Channelshypothalamusion channelreactive oxygen speciessynaptic transmission

Identifiers

PMID31042419
PMCPMC6692749
OpenAlexW2943795123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.