Evidence map›Paper›PMID 31042400›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2019

A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.

Anne-Marie Carreau, Eunsook S Jin, Yesenia Garcia-Reyes, Haseeb Rahat, Kristen J Nadeau, Craig R Malloy, Melanie Cree-Green

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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  7. Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anne-Marie CarreauDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Eunsook S JinAdvanced Imaging Research Center, University of Texas Southwestern Medical Center , Dallas, Texas.
Yesenia Garcia-ReyesDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Haseeb RahatDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Kristen J NadeauDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Craig R MalloyAdvanced Imaging Research Center, University of Texas Southwestern Medical Center , Dallas, Texas.
Melanie Cree-GreenDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Colorado Anschutz Medical Campus , Aurora, Colorado.ORCID 0000-0003-1593-1695
University of Colorado Anschutz Medical Campus · USSouthwestern Medical Center · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025780 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2008 to 2011
$61.3M
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI BURGESS, SHAWN C · 2012 to 2021
$10.9M
13C asymmetry in blood glucose as a marker for oxidative stress in liverR01DK099289 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JIN, EUNSOOK · 2014 to 2017
$1.1M
Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girlsK23DK107871 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CREE, MELANIE G · 2015 to 2018
$743k
The Next Generation of Innovative Cardiovascular Clinical/Translational ResearchersK24HL145076 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI NADEAU, KRISTEN JANE · 2019 to 2023
$574k
NCATS NIH HHS UL1 TR002535NCRR NIH HHS UL1 RR025780NHLBI NIH HHS K24 HL145076NIBIB NIH HHS P41 EB015908NIDDK NIH HHS K23 DK107871NIDDK NIH HHS R01 DK099289
6 · The paper itself

Abstract

Hepatic energy metabolism is a key element in many metabolic diseases. Hepatic anaplerosis provides carbons for gluconeogenesis (GNG) and triglyceride (TG) synthesis. We aimed to optimize a protocol that measures hepatic anaplerotic contribution for GNG, TG synthesis, and hepatic pentose phosphate pathway (PPP) activity using a single dose of oral [U

Indexed as

Pediatric ObesityPolycystic Ovary SyndromeAdolescentBlood GlucoseCarbon IsotopesFemaleGluconeogenesisGlucoseGlycerolHumansInsulin ResistanceLipogenesisLiverTriglyceridesYoung AdultBlood GlucoseCarbon IsotopesGlucoseGlycerolTriglyceridesanaplerosisgluconeogenesisinsulin resistanceliver metabolismmitochondriapentose phosphate pathwaypolycystic ovarian syndrome

Identifiers

PMID31042400
PMCPMC6692761
OpenAlexW2943365237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.