Evidence map›Paper›PMID 31042399›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019

Perinatal high-fat diet alters development of GABA

Courtney Clyburn, Caitlin A Howe, Amy C Arnold, Charles H Lang, R Alberto Travagli, Kirsteen N Browning

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Brain-gut communication: vagovagal reflexes interconnect the two "brains".American journal of physiology. Gastrointestinal and liver physiology · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Courtney ClyburnDepartment of Neural and Behavioral Sciences, Penn State College of Medicine , Hershey, Pennsylvania.ORCID 0000-0003-1300-3705
Caitlin A HoweDepartment of Neural and Behavioral Sciences, Penn State College of Medicine , Hershey, Pennsylvania.ORCID 0000-0002-7988-8406
Amy C ArnoldDepartment of Neural and Behavioral Sciences, Penn State College of Medicine , Hershey, Pennsylvania.ORCID 0000-0002-1380-6017
Charles H LangDepartment of Cellular and Molecular Physiology, Penn State College of Medicine , Hershey, Pennsylvania.
R Alberto TravagliDepartment of Neural and Behavioral Sciences, Penn State College of Medicine , Hershey, Pennsylvania.ORCID 0000-0003-2297-7683
Kirsteen N BrowningDepartment of Neural and Behavioral Sciences, Penn State College of Medicine , Hershey, Pennsylvania.ORCID 0000-0002-5062-3703
Penn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
Vagal Dysregulation in Neonatal Gastrointestinal PathologyR01DK099350 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KOPENHAVER DOHENY, KIM, TRAVAGLI, RENATO ALBERTO · 2014 to 2017
$2.2M
Influence of diet on the development of homeostatic neurocircuitsR01DK111667 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BROWNING, KIRSTEEN NAIRN · 2018 to 2021
$1.6M
Astrocyte-Dependent Modulation of Synaptic Strength in Response to Acute High Fat DietF31DK118833 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CLYBURN, COURTNEY E · 2019 to 2020
$64k
NCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NIDDK NIH HHS F31 DK118833NIDDK NIH HHS R01 DK099350NIDDK NIH HHS R01 DK111667
6 · The paper itself

Abstract

Perinatal high-fat diet (pHFD) exposure increases the inhibition of dorsal motor nucleus of the vagus (DMV) neurons, potentially contributing to the dysregulation of gastric functions. The aim of this study was to test the hypothesis that pHFD increases the inhibition of DMV neurons by disrupting GABA

Indexed as

Diet, High-FatGastrointestinal MotilityPrenatal Exposure Delayed EffectsAge FactorsAnimal Nutritional Physiological PhenomenaAnimalsBrain StemFemaleGene Expression Regulation, DevelopmentalGestational AgeInhibitory Postsynaptic PotentialsMaleMaternal Nutritional Physiological PhenomenaMiniature Postsynaptic PotentialsNeural InhibitionPregnancyGabra1 protein, ratGabra2 protein, ratGabra3 protein, ratReceptors, GABA-Abrainstemdevelopmenthigh-fat dietplasticityvagusγ-aminobutyric acid

Identifiers

PMID31042399
PMCPMC6689732
OpenAlexW2943046092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.