Evidence map›Paper›PMID 31042162›Full record

ArticleThe Journal of clinical investigation2019

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.

Bilon Khambu, Nazmul Huda, Xiaoyun Chen, Daniel J Antoine, Yong Li, Guoli Dai, Ulrike A Köhler, Wei-Xing Zong, Satoshi Waguri, Sabine Werner and 3 more

Abstract readExpression of Concern
In one paragraph

Article in The Journal of clinical investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Functional interplay between non-canonical inflammasomes and autophagy in inflammatory responses and diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Autophagy plays a double-edged sword role in liver diseases.Journal of physiology and biochemistry · 2022
    Review
  7. Role of HMGB1 in Vitiligo: Current Perceptions and Future Perspectives.Clinical, cosmetic and investigational dermatology · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Bilon Khambu
Nazmul Huda
Xiaoyun Chen
Daniel J Antoine
Yong Li
Guoli Dai
Ulrike A Köhler
Wei-Xing Zong
Satoshi Waguri
Sabine Werner
Tim D Oury
Zheng Dong
Xiao-Ming Yin

Funding

The dynamics and mechanisms of autophagy in ethanol - induced liver pathogenesisR01AA021751 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI TSUKAMOTO, HIDEKAZU, YIN, XIAO-MING · 2013 to 2017
$2.1M
NIAAA NIH HHS R01 AA021751
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID31042162
PMCPMC6486378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.