Evidence map›Paper›PMID 31042081›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

(Pro)renin receptor regulates lung development via the Wnt/β-catenin signaling pathway.

Jie Liu, Yafan Zhou, Yalan Liu, Lei Li, Yan Chen, Yali Liu, Yumei Feng, Ihor V Yosypiv, Renfang Song, Hua Peng

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jie LiuDepartment of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yafan ZhouDepartment of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yalan LiuDepartment of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lei LiDepartment of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yan ChenDepartment of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yali LiuDepartment of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yumei FengDepartment of Pharmacology, Center for Cardiovascular Research, University of Nevada School of Medicine, Reno, Nevada.
Ihor V YosypivDepartment of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana.
Renfang SongDepartment of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana.
Hua PengDepartment of Pediatrics, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-2862-315X
Union Hospital · CNTulane University · USHuazhong University of Science and Technology · CNUniversity of Nevada, Reno · US

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Nathan Grainger · 2019 to 2026
$20.3M
The Neural Mechanisms of HypertensionR01HL122770 · NHLBI · UNIVERSITY OF ROCHESTER · PI FENG EARLEY, YUMEI · 2015 to 2023
$4.2M
NHLBI NIH HHS R01 HL122770NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

The (pro)renin receptor [(P)RR] binds to prorenin to activate the renin-angiotensin system and is essential for the development of many different organ systems. Whether the (P)RR also plays a role in lung development is unknown. Immunostaining was used to determine the spatial-temporal distribution of (P)RR in the embryonic, postnatal, and adult lungs. We created a lung-specific (P)RR knockout mouse [

Indexed as

AnimalsCell DifferentiationCell ProliferationDown-RegulationLungMice, Inbred C57BLMorphogenesisOrganogenesisProrenin ReceptorReceptors, Cell SurfaceReninVacuolar Proton-Translocating ATPasesWnt Signaling PathwayATP6AP2 protein, humanProrenin ReceptorReceptors, Cell SurfaceReninVacuolar Proton-Translocating ATPaseslung development(Pro)rennin receptorWnt/β-catenin signaling

Identifiers

PMID31042081
PMCPMC6734386
OpenAlexW2943472874

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.