Evidence map›Paper›PMID 31042080›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019

Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model.

Elizabeth R Vogel, Logan J Manlove, Ine Kuipers, Michael A Thompson, Yun-Hua Fang, Michelle R Freeman, Rodney D Britt, Arij Faksh, Binxia Yang, Y S Prakash and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Exogenous hydrogen sulfide attenuates hyperoxia effects on neonatal mouse airways.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  5. Review
  6. Caveolin-1 negatively regulates inflammation and fibrosis in silicosis.Journal of cellular and molecular medicine · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elizabeth R VogelDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Logan J ManloveDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Ine KuipersDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Michael A ThompsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Yun-Hua FangDepartment of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.
Michelle R FreemanDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Rodney D BrittDepartment of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, Minnesota.ORCID 0000-0002-0027-9545
Arij FakshDepartment of Obstetrics and Gynecology, Mayo Clinic , Rochester, Minnesota.
Binxia YangDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.ORCID 0000-0002-2968-224X
Christina M PabelickDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic , Rochester, Minnesota.
Mayo Clinic · US

Funding

NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Neurotrophins in the LungR01HL088029 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 2009 to 2022
$5.9M
Interdisciplinary Training in Lung Physiology and Biomedical EngineeringT32HL105355 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2012 to 2021
$3.9M
Understanding CPAP Effects in the Developing AirwayR01HL138402 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MACFARLANE, PETER · 2017 to 2020
$2.5M
Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung DiseaseR00HL131682 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRITT, RODNEY · 2018 to 2020
$845k
Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung DiseaseK99HL131682 · NHLBI · MAYO CLINIC ROCHESTER · PI BRITT, RODNEY · 2017 to 2018
$301k
NHLBI NIH HHS K99 HL131682NHLBI NIH HHS R00 HL131682NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL088029NHLBI NIH HHS R01 HL138402NHLBI NIH HHS T32 HL105355
6 · The paper itself

Abstract

Reactive airway diseases are significant sources of pulmonary morbidity in neonatal and pediatric patients. Supplemental oxygen exposure in premature infants contributes to airway diseases such as asthma and promotes development of airway remodeling, characterized by increased airway smooth muscle (ASM) mass and extracellular matrix (ECM) deposition. Decreased plasma membrane caveolin-1 (CAV1) expression has been implicated in airway disease and may contribute to airway remodeling and hyperreactivity. Here, we investigated the impact of clinically relevant moderate hyperoxia (50% O

Indexed as

Airway RemodelingAnimalsAnimals, NewbornAnti-Inflammatory AgentsBronchial HyperreactivityBronchoconstrictor AgentsCaveolin 1Disease Models, AnimalFemaleGene Expression RegulationHumansHyperoxiaInjections, IntraperitonealLungMaleMembrane ProteinsAnti-Inflammatory AgentsBronchoconstrictor AgentsCav1 protein, mouseCaveolin 1caveolin-1 (82-101)Cavin1 protein, mouseMembrane ProteinsMethacholine ChlorideOxygenPeptide FragmentsRNA-Binding Proteinsairway smooth muscleasthmacaveolin-1extracellular matrixhyperoxianeonatal

Identifiers

PMID31042080
PMCPMC6689745
OpenAlexW2943616268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.