ArticleAmerican journal of physiology. Lung cellular and molecular physiology2019
Acute exposure to e-cigarettes causes inflammation and pulmonary endothelial oxidative stress in nonsmoking, healthy young subjects.
Article in American journal of physiology. Lung cellular and molecular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03479203 (Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity), which is not on this map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Guideline
- The impact of electronic cigarettes on the outcomes of total joint arthroplasty.Archives of orthopaedic and trauma surgery · 2024Pooled it
- E-cigarette use and respiratory disorders: an integrative review of converging evidence from epidemiological and laboratory studies.The European respiratory journal · 2021Pooled it
- Metabolic disruption associated with e-cigarette vaping and secondhand exposure: Urinary metabolomics evidence from a Thai population.Toxicology reports · 2026Article
- Electronic cigarettes, endothelial dysfunction, and erectile health: an emerging sexual medicine concern.International journal of impotence research · 2026Review
- Molecular Health Effects of Electronic Cigarettes.Biomolecules · 2026Review
- Smoking accelerates immunosenescence in multiple sclerosis.Frontiers in immunology · 2026Review
- Circadian Control of Pulmonary Endothelial Signaling Occurs via the NADPH Oxidase 2-NLRP3 Pathway.Journal of biological rhythms · 2025Article
- E-cigarette exposure and CDP choline modulate withdrawal- induced anxiety and hormonal levels in rats.Scientific reports · 2025Article
- Methods for Vaping Cessation Among Young Adults in Southern California.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- The respiratory epithelium in the era of vaping: insights fromEuropean respiratory review : an official journal of the European Respiratory Society · 2025Review
- Comparative Analysis of Inflammatory and Heavy Metal Biomarkers in Exclusive E-Cigarette Users, Combustible Tobacco Users, and Non-Users Aged 18-30: A Cross-Sectional NHANES Analysis.Journal of xenobiotics · 2025Article
- E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025Review
- E-Cigarettes induce expression of procoagulant tissue factor in cultivated human endothelial cells.Journal of thrombosis and thrombolysis · 2025Article
- Nicotine-free electronic vape fluid stimulates angiogenic processesFrontiers in toxicology · 2025Article
- Vaping leads tobacco consumption among university students in Arab countries: a study of behavioral and psychosocial factors associated with smoking.Frontiers in public health · 2025Article
- Comparative assessment of respiratory, hematological and inflammatory profiles of long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia.Tobacco induced diseases · 2025Article
- E-cigarettes and arterial health: A review of the link between vaping and atherosclerosis progression.World journal of cardiology · 2024Review
- Vaping causes an acute BMI-dependent change in pulmonary blood flow.Physiological reports · 2024Article
- An electron paramagnetic resonance time-course study of oxidative stress in the plasma of electronic cigarette exposed rats.Experimental physiology · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The effects of e-cigarette (e-cig) aerosol inhalation by nonsmokers have not been examined to date. The present study was designed to evaluate the acute response to aerosol inhalation of non-nicotinized e-cigarettes in terms of oxidative stress and indices of endothelial activation in human pulmonary microvascular endothelial cells (HPMVEC). Ten smoking-naïve healthy subjects (mean age ± SD = 28.7 ± 5.5 yr) were subjected to an e-cig challenge, following which their serum was monitored for markers of inflammation [C-reactive protein (CRP) and soluble intercellular adhesion molecule (sICAM)] and nitric oxide metabolites (NOx). The oxidative stress and inflammation burden of the circulating serum on the vascular network was also assessed by measuring reactive oxygen species (ROS) production and induction of ICAM-1 expression on HPMVEC. Our results show that serum indices of oxidative stress and inflammation increased significantly (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.