ArticleAmerican journal of physiology. Renal physiology2019
Characterizing novel olfactory receptors expressed in the murine renal cortex.
Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Ectopic Olfactory Receptors in Oral Health and Disease: Molecular Links Between Chemosensing, Tissue Repair, Inflammation, and Cancer.International journal of molecular sciences · 2026Review
- Therapeutic strategies for hypertension: exploring the role of microbiota-derived short-chain fatty acids in kidney physiology and development.Pediatric nephrology (Berlin, Germany) · 2026Review
- The free fatty acid receptor GPR164 maintains intestinal homeostasis and barrier function.EMBO reports · 2025Article
- Article
- Roles of sensory receptors in non-sensory organs: the kidney and beyond.Nature reviews. Nephrology · 2025Review
- A guide to studying 3D genome structure and dynamics in the kidney.Nature reviews. Nephrology · 2025Review
- Genome-wide association analysis of cystatin c and creatinine kidney function in Chinese women.BMC medical genomics · 2024Article
- New insights into the roles of olfactory receptors in cardiovascular disease.Molecular and cellular biochemistry · 2024Review
- An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure.Science advances · 2024Article
- The effect of oral butyrate on colonic short-chain fatty acid transporters and receptors depends on microbial status.Frontiers in pharmacology · 2024Article
- Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family.Nature communications · 2023Article
- A Two-Step Transcriptome Analysis of the Human Heart Reveals Broad and Disease-Responsive Expression of Ectopic Olfactory Receptors.International journal of molecular sciences · 2023Article
- Short-Chain Fatty Acid Receptors and Blood Pressure Regulation: Council on Hypertension Mid-Career Award for Research Excellence 2021.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Key amino acids alter activity and trafficking of a well-conserved olfactory receptor.American journal of physiology. Cell physiology · 2022Article
- Understudied G Protein-Coupled Receptors in the Kidney.Nephron · 2022Review
- Olfactory receptor 78 modulates renin but not baseline blood pressure.Physiological reports · 2021Article
- Landscape of GPCR expression along the mouse nephron.American journal of physiology. Renal physiology · 2021Article
- Kidney physiology: our future is now.American journal of physiology. Renal physiology · 2021Article
- Identification of novel bladder sensory GPCRs.Physiological reports · 2021Article
- Oral Signals of Short and Long Chain Fatty Acids: Parallel Taste Pathways to Identify Microbes and Triglycerides.Current opinion in physiology · 2021Article
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7 authors at 2 institutions in 1 country.
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Abstract
The kidney uses specialized G protein-coupled receptors, including olfactory receptors (ORs), to act as sensors of molecules and metabolites. In the present study, we cloned and studied seven renal ORs, which we previously found to be expressed in the murine renal cortex. As most ORs are orphan receptors, our goal was to identify ligands for these ORs in the hope that this will guide future research into their functional roles. We identified novel ligands for two ORs: Olfr558 and Olfr90. For Olfr558, we confirmed activation by previously reported ligands and identified 16 additional carboxylic acids that activated this OR. The strongest activation of Olfr558 was produced by butyric, cyclobutanecarboxylic, isovaleric, 2-methylvaleric, 3-methylvaleric, 4-methylvaleric, and valeric acids. The primary in vivo source of both butyric and isovaleric acids is gut microbial metabolism. We also identified 14 novel ligands that activated Olfr90, the strongest of which were 2-methyl-4-propyl-1,3-oxathiane, 1-octen-3-ol, 2-octanol, and 3-octanol. Interestingly, 8 of these 14 ligands are of fungal origin. We also investigated the tissue distribution of these receptors and found that they are each found in a subset of "nonsensory" tissues. Finally, we examined the putative human orthologs of Olfr558 and Olfr90 and found that the human ortholog of Olfr558 (OR51E1) has a similar ligand profile, indicating that the role of this OR is likely evolutionarily conserved. In summary, we examined seven novel renal ORs and identified new ligands for Olfr558 and Olfr90, which imply that both of these receptors serve to detect metabolites produced by microorganisms.
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