Evidence map›Paper›PMID 31041926›Full record

ArticleThe international journal of occupational and environmental medicine2019

Effects of delta-Aminolevulinic Acid Dehydratase Gene Polymorphism on Hematological Parameters and Kidney Function of Lead-exposed Workers.

Mona Sobhi Siha, Dalia Abdel-Hamid Shaker, Hebatalla Saad Teleb, Laila Ahmed Rashed

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of occupational and environmental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mona Sobhi SihaDepartment of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Egypt.
Dalia Abdel-Hamid ShakerDepartment of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Egypt. dalia.shaker@kasralainy.edu.eg.
Hebatalla Saad TelebDepartment of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Egypt.
Laila Ahmed RashedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Egypt.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead exposure is associated with several health hazards among workers with different individual responses. We conducted this study to determine the possible effects of lead exposure on hematological parameters and kidney function of a group of Egyptian ammunition workers and the interaction of aminolevulinic acid dehydratase (ALAD) G177C gene polymorphisms as an effect modifier. Significant differences were observed between exposed workers with ALAD1-1 and ALAD1-2 genotypes in terms of blood lead level, hematological parameters and kidney function. It seems that δ-ALAD gene polymorphism may be an effect modifier and a marker of genetic susceptibility to lead toxicity.

Indexed as

Occupational ExposurePolymorphism, GeneticBiomarkersCross-Sectional StudiesEgyptGenetic Predisposition to DiseaseHumansKidneyKidney Function TestsLeadMaleMiddle AgedPorphobilinogen SynthaseBiomarkersLeadPorphobilinogen Synthasebeta 2-MicroglobulinExplosive agentsLeadPolymorphism, geneticPorphobilinogen synthase

Identifiers

PMID31041926
PMCPMC6524739
OpenAlexW2943667363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.