ArticleCancer medicine2019
Multiple exposure to environmental factors and variations in CYP27B1 and the microRNA-binding site of IL-13 are associated with breast cancer risk.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 2 citations in OpenAlex.
- Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women.Frontiers in medicine · 2026Article
- Effects of marital status on overall and cancer-specific survival in laryngeal cancer patients: a population-based study.Scientific reports · 2021Article
- Marital status impacts survival in patients with upper tract urothelial carcinoma: a population-based, propensity-matched study.Translational andrology and urology · 2020Article
- Multiple exposure to environmental factors and variations in CYP27B1 and the microRNA-binding site of IL-13 are associated with breast cancer risk.Cancer medicine · 2019Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSeveral molecular epidemiology studies have evidenced an association of environmental factors and genetic polymorphisms with breast cancer (BC) risk. However, most have considered the functions of a single element rather than combined effects.
methodsThis case-control study of 693 newly-diagnosed BC cases and 714 cancer-free controls evaluated the effect of multiple exposures to environmental factors and polymorphisms in CYP27B1 and IL-13 on BC risk. Genotypes were detected using TaqMan genotyping. Combinations and interactions were analyzed using cross-over analysis and multivariate logistic regression. Combining exposure models were assessed using classification and regression tree and multivariate logistic regression analyses.
resultsNo significant independent association was observed for any polymorphism in CYP27B1 or IL-13 with the risk of BC. However, significant combined effects were noted for ≥1 time/wk physical activity with rs10877012 (adjusted odds ratio [OR
conclusionsOur findings suggest that personalized adjustments to diet and behavioral patterns may aid BC prevention in variant carriers of CYP27B1 and IL-13.
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