Evidence map›Paper›PMID 31041657›Full record

ArticleMolecular neurobiology2019

Prion Efficiently Replicates in α-Synuclein Knockout Mice.

Edoardo Bistaffa, Martina Rossi, Chiara Maria Giulia De Luca, Federico Cazzaniga, Olga Carletta, Ilaria Campagnani, Fabrizio Tagliavini, Giuseppe Legname, Giorgio Giaccone, Fabio Moda

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Is Multiple System Atrophy a Prion-like Disorder?International journal of molecular sciences · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Edoardo BistaffaUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Martina RossiDepartment of Neuroscience, Laboratory of Prion Biology, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.
Chiara Maria Giulia De LucaUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Federico CazzanigaUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Olga CarlettaUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Ilaria CampagnaniUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Fabrizio TagliaviniUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Giuseppe LegnameDepartment of Neuroscience, Laboratory of Prion Biology, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.
Giorgio GiacconeUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Fabio ModaUnit of Neuropathology and Neurology 5, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. fabio.moda@istituto-besta.it.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITScuola Internazionale Superiore di Studi Avanzati · IT

Funding

Ministero della Salute RC
6 · The paper itself

Abstract

Prion diseases are a group of neurodegenerative disorders associated with the conformational conversion of the cellular prion protein (PrP

Indexed as

alpha-SynucleinAnimalsBrainEndopeptidase KMice, Inbred C57BLMice, KnockoutPrionsProtein Foldingalpha-SynucleinEndopeptidase KPrionsPMCAPrionsRMLα-Synuclein

Identifiers

PMID31041657
OpenAlexW2943115467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.