ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2020
Adherence to the guidelines and the pathological diagnosis of high-risk gastrointestinal stromal tumors in the real world.
Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 26 citations in OpenAlex.
- Development and validation of an endoscopic ultrasound-based nomogram for differentiating small gastric stromal tumours from non-gastric stroma tumours.Surgical endoscopy · 2026Article
- Ultrasound elastography for the differential diagnosis of benign and malignant gastrointestinal stromal tumors.World journal of gastrointestinal surgery · 2025Article
- Colonic Gastrointestinal Stromal Tumors Demonstrate Unique Biological Characteristics: A Retrospective, Propensity Score-Matched Cohort Study Pooling Multicenter and Literature-Derived Individual Patient Data.Clinical Medicine Insights. Oncology · 2025Article
- Molecular and clinicopathological features of KIT/PDGFRA wild-type gastrointestinal stromal tumors.Cancer science · 2024Article
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- Referral patterns of GIST patients: data from a nationwide study.Acta oncologica (Stockholm, Sweden) · 2024Article
- Comparison of radiological and pathological tumor sizes in resected non-small cell lung cancer.General thoracic and cardiovascular surgery · 2023Article
- Re-appraisal of the universal definition of tumor rupture among patients with high-risk gastrointestinal stromal tumors.Annals of gastroenterological surgery · 2023Article
- Clinicopathological, immunohistochemical, molecular-genetic and risk profiles of gastrointestinal stromal tumors in a cohort of Sudanese patients.African health sciences · 2023Article
- Guideline adherence and implementation of tumor board therapy recommendations for patients with gastrointestinal cancer.Journal of cancer research and clinical oncology · 2023Article
- Endoscopic Ultrasound Advanced Techniques for Diagnosis of Gastrointestinal Stromal Tumours.Cancers · 2023Review
- Preoperative prediction of malignant potential of 2-5 cm gastric gastrointestinal stromal tumors by computerized tomography-based radiomics.World journal of gastrointestinal oncology · 2022Article
- Real-world data on the efficacy and safety of adjuvant chemotherapy in Japanese patients with a high-risk of gastrointestinal stromal tumor recurrence.International journal of clinical oncology · 2022Article
- Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer.International journal of general medicine · 2022Article
- Nationwide evaluation of mutation-tailored treatment of gastrointestinal stromal tumors in daily clinical practice.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- Preoperative CT feature of incomplete overlying enhancing mucosa as a high-risk predictor in gastrointestinal stromal tumors of the stomach.European radiology · 2021Article
- Clinicopathological characteristics and prognosis of gastrointestinal stromal tumors containing air-fluid levels.PloS one · 2021Article
- Correlation analysis of multi-slice computed tomography (MSCT) findings, clinicopathological factors, and prognosis of gastric gastrointestinal stromal tumors.Translational cancer research · 2020Article
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11 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundA multidisciplinary approach based on guidelines and pathological diagnosis by specialized pathologists are important for improving the prognosis and QoL of GIST patients. This study examined the adherence to the guidelines and the concordance of the pathological diagnosis of high-risk GISTs. PATIENTS AND
methodsAmong 541 patients with high-risk GISTs recruited to the prospective registry between Dec. 2012 and Dec. 2015, 534 patients were analyzed after central pathology with KIT and DOG1 IHC and genotyping of KIT and PDGFRA.
resultsOf the 534 patients, 432 (81%) received imatinib adjuvant therapy at a starting dose of 400 or 300 mg/day. Multivariate analysis indicated that age (HR 0.71; 95% CI 0.58-0.88), tumor size (HR for > 10 cm vs < 5 cm, 3.87; 95% CI 1.72-8.74), mitosis (HR for > 10 vs < 5, 3.54; 95% CI 1.84-6.79), tumor rupture (HR 3.69; 95% CI 1.43-9.52) and performance status (HR 0.55; 95% CI 0.31-0.99) were independently related to adjuvant therapy. Among the 534 high-risk GISTs diagnosed locally, 19 tumors (3.6%) were diagnosed as non-GISTs, and the other 93 (18.1%) GISTs were reclassified into lower risk categories by central pathology. Among 10 patients with non-GISTs and 8 patients with PDGFRA D842V mutations, 4 (40%) and 3 (38%) patients, respectively, continued the therapy after receiving the central pathology results.
conclusionsThe adherence to guidelines and the concordance of pathological diagnoses were comparatively good for high-risk GISTs. Central pathology may contribute to improved diagnosis, but further refinements may be required.
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