Evidence map›Paper›PMID 31041609›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis.

Alison Barry, Owen Cronin, Aisling M Ryan, Brian Sweeney, Orna O'Toole, Ken D O'Halloran, Eric J Downer

Erratum issuedAbstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Alison BarryDepartment of Physiology, School of Medicine, Western Gateway Building, University College Cork, Cork, Ireland.
Owen CroninDepartment of Medicine, Cork University Hospital, Cork, Ireland.
Aisling M RyanDepartment of Neurology, Cork University Hospital, Cork, Ireland.
Brian SweeneyDepartment of Neurology, Cork University Hospital, Cork, Ireland.
Orna O'TooleMercy University Hospital, Cork, Ireland.
Ken D O'HalloranDepartment of Physiology, School of Medicine, Western Gateway Building, University College Cork, Cork, Ireland.
Eric J DownerDepartment of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland. edowner@tcd.ie.ORCID http://orcid.org/0000-0002-6012-2291
Cork University Hospital · IEUniversity College Cork · IEMercy University Hospital · IETrinity College Dublin · IE

Funding

Physiological Society 444
6 · The paper itself

Abstract

The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65-75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.

Indexed as

BicyclingAdultErgometryExercise TherapyHumansInterleukin-10Interleukin-12 Subunit p35Interleukin-6Multiple SclerosisIL10 protein, humanIL12A protein, humanIL6 protein, humanInterleukin-10Interleukin-12 Subunit p35Interleukin-6CytokinesExerciseInterleukin-10Multiple sclerosisPlasma

Identifiers

PMID31041609
OpenAlexW2943044116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.