ArticleEuropean radiology2019
Prediction of esophageal varices by liver and spleen MR elastography.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of spleen stiffness to evaluate portal hypertension and esophageal varices in chronic liver disease: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Development and evaluation of a predictive model based on multi-frequency magnetic resonance elastography for high-risk esophagogastric varices in patients with cirrhotic portal hypertension.Insights into imaging · 2026Article
- Preliminary quantitative assessment of liver and spleen MR imaging and elastography in clinically significant portal hypertension.Scientific reports · 2026Article
- Role of liver transient elastography in detecting cirrhosis with esophageal and gastric varices and evaluating variceal severity.BMC gastroenterology · 2025Article
- Predictive value of high-risk esophageal varices in cirrhosis based on dual-energy CT combined with clinical and serologic features.BMC medical imaging · 2025Article
- Application of machine learning methods for predicting esophageal variceal bleeding in patients with cirrhosis.European radiology · 2025Article
- Superiority of spleen stiffness on two-dimensional magnetic resonance elastography over liver stiffness and serum tests in assessing portal hypertension in chronic liver disease.Quantitative imaging in medicine and surgery · 2024Article
- Spleen stiffness measurement as a non-invasive assessment in patients with portal hypertension.eGastroenterology · 2024Review
- The Value of Follow-Up Liver Stiffness Changes Measured by Virtual Touch Quantification Elastography for Predicting Recurrence of Gastroesophageal Varices after Endoscopic Injection Sclerotherapy on Cirrhotic Patients.Gastroenterology research and practice · 2024Article
- Diagnostic Accuracy of Liver and Spleen Stiffness in Magnetic Resonance Elastography for the Detection of Gastroesophageal Varices: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2023Review
- Spleen stiffness determined by spleen-dedicated device accurately predicted esophageal varices in cirrhosis patients.Therapeutic advances in chronic disease · 2023Article
- Liver fibrosis assessment: MR and US elastography.Abdominal radiology (New York) · 2022Review
- Derivation of "Egyptian varices prediction (EVP) index": A novel noninvasive index for diagnosing esophageal varices in HCV Patients.Journal of advanced research · 2022Article
- An index based on deep learning-measured spleen volume on CT for the assessment of high-risk varix in B-viral compensated cirrhosis.European radiology · 2021Article
- Magnetic resonance parametric mapping of the spleen for non-invasive assessment of portal hypertension.European radiology · 2021Article
- MR elastography of liver: current status and future perspectives.Abdominal radiology (New York) · 2020Review
- Advances in Magnetic Resonance Elastography of Liver.Magnetic resonance imaging clinics of North America · 2020Review
- Noninvasive evaluation of esophageal varices in cirrhotic patients based on spleen hemodynamics: a dual-energy CT study.European radiology · 2020Article
- Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.European radiology · 2020Article
- Validation and Refinement of the Baveno VI Criteria for Ruling Out High-Risk Varices.Gastroenterology research and practice · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesWe aimed to assess the diagnostic performance of MR elastography (MRE) in predicting esophageal varices (EVs) in patients with chronic liver disease.
methodsWe prospectively performed liver (LSM) and spleen stiffness measurements (SSM) using MRE and endoscopic screening for EVs to determine if patients with hepatocellular carcinoma were eligible for resection. We investigated whether LSM, SSM, and other non-invasive preoperative parameters were associated with the presence of EVs. In order to predict EVs, 211 patients were divided into training (n = 140) and test (n = 71) groups. A nomogram was built using independent factors based on logistic regression analysis in the training group and its accuracy was validated using an independent cohort.
resultsForty-six patients (21.8%) were diagnosed as having EVs (mild, n = 36; severe, n = 10). According to multiple regression analysis, LSM (odds ratio, 2.362; 95% confidence interval [CI], 1.341-4.923; p = 0.001) and SSM (1.489; 1.095-2.235; p = 0.010) were independent predictors of EVs in the training group. The nomogram showed good discrimination, with a C-index of 0.942 (95% CI, 0.892-0.974) through internal validation, and good calibration. Application of the nomogram in the test group still gave good discrimination (C-index, 0.948; 95% CI, 0.868-0.995).
conclusionsThe combination of LSM and SSM using MRE is an accurate tool to identify patients at risk for EVs. KEY POINTS: • Performance of MR elastography can estimate the presence of esophageal varices non-invasively. • Liver and spleen stiffness measurements are independent predictors for esophageal varices. • The nomogram using a combination of liver and spleen stiffness measurements allows for the risk of esophageal varices.
Indexed as
Identifiers
31041563What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.