Evidence map›Paper›PMID 31041529›Full record

ArticleMikrochimica acta2019

A fluorometric aptamer nanoprobe for alpha-fetoprotein by exploiting the FRET between 5-carboxyfluorescein and palladium nanoparticles.

Guiyin Li, Junxiang Zeng, Huiling Liu, Ping Ding, Jintao Liang, Xinmin Nie, Zhide Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Guiyin LiSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541004, Guangxi, China.
Junxiang ZengSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541004, Guangxi, China.
Huiling LiuSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541004, Guangxi, China.
Ping DingXiang Ya School of Public Health, Central South University, Changsha, 410078, Hunan, China.
Jintao LiangSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541004, Guangxi, China.
Xinmin NieClinical Laboratory of the Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. niexinmin7440@sina.com.
Zhide ZhouSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541004, Guangxi, China. zzdlgy@163.com.
Guilin University of Electronic Technology · CNCentral South University · CNThird Xiangya Hospital · CN

Funding

Fund of the College students' innovative projects of Guangxi province 201710595110Guangxi Key Laboratory of Automatic Detection Technology and Instrument Foundation YQ17114National Natural Science Foundation of China 81760534the Fund of the College students' innovative projects 201810595006
6 · The paper itself

Abstract

Alpha-fetoprotein (AFP) is a reliable clinical marker of hepatocellular carcinoma (HCC). A highly sensitive fluorometric aptamer nanoprobe is described for AFP detection. It is based on fluorescence resonance energy transfer (FRET) between AFP aptamer labelled with 5-carboxyfluorescein (FAM) and palladium nanoparticles (PdNPs). The PdNPs quench the green fluorescence of the FAM-AFP aptamer via interactions between nitrogen functional groups of the AFP aptamer and PdNPs. When AFP was introduced into the FAM-AFP aptamer-PdNPs FRET system, the AFP aptamer preferentially combines with AFP. This results in a conformational change and weakens the interaction between the aptamer and the PdNPs. Thus, the fluorescence of FAM recovers. The fluorescence recovery of FAM increases linearly in the 5.0-150 ng·mL

Indexed as

alpha-FetoproteinsAnimalsAptamers, NucleotideBase SequenceBiosensing TechniquesFeasibility StudiesFluoresceinsFluorescence Resonance Energy TransferFluorometryHumansHydrogen-Ion ConcentrationMetal NanoparticlesNanostructuresPalladium4-carboxyfluoresceinalpha-FetoproteinsAptamers, NucleotideFluoresceinsPalladiumAlpha-fetoproteinAptamerFluorescence resonance energy transferPalladium nanoparticles

Identifiers

PMID31041529
OpenAlexW2942514420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.