Evidence map›Paper›PMID 31041527›Full record

ArticleCardiovascular and interventional radiology2019

Robotically Assisted Sonic Therapy (RAST) for Noninvasive Hepatic Ablation in a Porcine Model: Mitigation of Body Wall Damage with a Modified Pulse Sequence.

Katherine C Longo, Emily A Knott, Rao F Watson, John F Swietlik, Eli Vlaisavljevich, Amanda R Smolock, Zhen Xu, Clifford S Cho, Lu Mao, Fred T Lee and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2021
    Pooled it
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  8. Histotripsy of the hepatic capsule and the gastric wall: acute treatment effects in a swine model.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2025
    Article
  9. Review
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  15. Safety and efficacy of histotripsy delivery through overlying gas-filled small bowel in an ex vivo swine model.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024
    Article
  16. Insights fromInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024
    Review
  17. Review
  18. Hepatic and Renal Histotripsy in an Anticoagulated Porcine Model.Journal of vascular and interventional radiology : JVIR · 2023
    Article
  19. Article
  20. Clinical translation of abdominal histotripsy: a review of preclinical studies in large animal models.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Katherine C LongoDepartment of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI, 53705, USA. klongo@uwhealth.org.ORCID http://orcid.org/0000-0002-7775-5482
Emily A KnottDepartment of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI, 53705, USA.
Rao F WatsonDepartment of Pathology, University of Wisconsin, Madison, USA.
John F SwietlikDepartment of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI, 53705, USA.
Eli VlaisavljevichDepartment of Biomedical Engineering and Mechanics, Virginia Polytechnic and State University, Blacksburg, USA.
Amanda R SmolockDivision of Interventional Radiology, Department of Radiology, University of Pennsylvania, Philadelphia, USA.
Zhen XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Clifford S ChoDepartment of Surgery, University of Michigan, Ann Arbor, USA.
Lu MaoDepartment of Biostatistics and Medical Informatics, University of Wisconsin, Madison, USA.
Fred T LeeDepartment of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI, 53705, USA.
Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Ave, Madison, WI, 53705, USA.
UW Health University Hospital · USUniversity of Wisconsin–Madison · USUniversity of Michigan · USUniversity of Pennsylvania · USVirginia Tech · US

Funding

Novel, Noninvasive, Rapid Tumor Ablation Technology using HistotripsyR01CA211217 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2018 to 2022
$2.7M
NCI NIH HHS R01 CA211217
6 · The paper itself

Abstract

purposeRobotically assisted sonic therapy (RAST) is a nonthermal, noninvasive ablation method based on histotripsy. Prior animal studies have demonstrated the ability to create hepatic ablation zones at the focal point of an ultrasound therapy transducer; however, these treatments resulted in thermal damage to the body wall within the path of ultrasound energy delivery. The purpose of this study was to evaluate the efficacy and safety of a pulse sequence intended to mitigate prefocal body wall injury. MATERIALS AND

methodsHealthy swine (n = 6) underwent hepatic RAST (VortxRx software version 1.0.1.3, HistoSonics, Ann Arbor MI) in the right hepatic lobe. A 3.0 cm spherical ablation zone was prescribed for each. Following treatment, animals underwent MRI which was utilized for ablation zone measurement, evaluation of prefocal injury, and assessment of complications. Each animal was euthanized, underwent necropsy, and the tissue was processed for histopathologic analysis of the ablation zone and any other sites concerning for injury.

resultsNo prefocal injury was identified by MRI or necropsy in the body wall or tissues overlying the liver. Ablation zones demonstrated uniform cell destruction, were nearly spherical (sphericity index = 0.988), and corresponded closely to the prescribed size (3.0 × 3.1 × 3.4 cm, p = 0.70, 0.36, and 0.01, respectively). Ablation zones were associated with portal vein (n = 3, one occlusive) and hepatic vein thrombosis (n = 4, one occlusive); however, bile ducts remained patent within ablation zones (n = 2).

conclusionsHepatic RAST performed with a modified ultrasound pulse sequence in a porcine model can mitigate prefocal body wall injuries while maintaining treatment efficacy. Further study of hepatic RAST appears warranted, particularly in tumor models.

Indexed as

Ablation TechniquesAnimalsFemaleLiverMagnetic Resonance ImagingModels, AnimalRobotic Surgical ProceduresSwineTreatment OutcomeUltrasonic TherapyAblationHistotripsyInterventional oncologyRASTUltrasound

Identifiers

PMID31041527
PMCPMC7456499
OpenAlexW2943605826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.