Evidence map›Paper›PMID 31041459›Full record

ReviewPsychopharmacology2019

Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy.

Shakuntla Gondalia, Lisa Parkinson, Con Stough, Andrew Scholey

Abstract readReview
PubMed Publisher
In one paragraph

Review in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shakuntla GondaliaCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, 3122, Australia. sgondalia@swin.edu.au.
Lisa ParkinsonCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, 3122, Australia.
Con StoughCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, 3122, Australia.
Andrew ScholeyCentre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Victoria, 3122, Australia.
Swinburne University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing evidence that connections formed between microbiome, the gut, and the brain play a role in health and well-being. Non-pharmaceutical targets for management of mood disorders, such as bipolar disorder, are relatively under-researched. At the same time, it is clear that there is an intimate connection between psychiatry and gastrointestinal health. Here, we have discussed various comorbid conditions associated with bipolar disorders such as inflammation, irritable bowel disease and antibiotic induced mania with importance to demonstrate possible involvement of the gut microbiota. Gut microbiota-targeted preclinical and clinical interventions have demonstrated enhancement in various psychological conditions. Further in this review, we explore links between bipolar disorder, inflammation and gut microbiome with a focus on dietary, pro- and pre-biotic interventions as potential adjuvant therapies for use in the management of mood disorders such as bipolar disorder.

Indexed as

Anti-Bacterial AgentsBipolar DisorderBrainDrug Therapy, CombinationGastrointestinal MicrobiomeHumansInflammation MediatorsMicrobiotaPrebioticsProbioticsAnti-Bacterial AgentsInflammation MediatorsPrebioticsAdjuvant therapyAntibiomaniaAntibioticBipolar disorderGut microbiomeImmunityInflammationProbiotics

Identifiers

PMID31041459
OpenAlexW2942526656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.