Evidence map›Paper›PMID 31041431›Full record

ArticleProceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data2018

Knowledge-Guided Bayesian Support Vector Machine for High-Dimensional Data with Application to Analysis of Genomics Data.

Wenli Sun, Changgee Chang, Yize Zhao, Qi Long

Abstract read
In one paragraph

Article in Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Graph-guided Bayesian SVM with Adaptive Structured Shrinkage Prior for High-dimensional Data.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2021
    Article
  6. Bayesian Non-linear Support Vector Machine for High-Dimensional Data with Incorporation of Graph Information on Features.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2019
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenli SunDepartment of Biostatistics, Epidemiology and Informatics The University of Pennsylvania, Philadelphia, PA, 19104.
Changgee ChangDepartment of Biostatistics, Epidemiology and Informatics The University of Pennsylvania, Philadelphia, PA, 19104.
Yize ZhaoDepartment of Healthcare Policy and Research Weill Cornell Medicine, Cornell University, New York, NY, 10065.
Qi LongDepartment of Biostatistics, Epidemiology and Informatics The University of Pennsylvania, Philadelphia, PA, 19104.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
Privacy-preserving methods and tools for handling missing data in distributed health data networksR01GM124111 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2017 to 2020
$2.3M
NCI NIH HHS P30 CA016520NIGMS NIH HHS R01 GM124111
6 · The paper itself

Abstract

Support vector machine (SVM) is a popular classification method for the analysis of wide range of data including big data. Many SVM methods with feature selection have been developed under frequentist regularization or Bayesian shrinkage frameworks. On the other hand, the importance of incorporating a priori known biological knowledge, such as gene pathway information which stems from the gene regulatory network, into the statistical analysis of genomic data has been recognized in recent years. In this article, we propose a new Bayesian SVM approach that enables the feature selection to be guided by the knowledge on the graphical structure among predictors. The proposed method uses the spike-and-slab prior for feature selection, combined with the Ising prior that encourages group-wise selection of the predictors adjacent to each other on the known graph. Gibbs sampling algorithm is used for Bayesian inference. The performance of our method is evaluated and compared with existing SVM methods in terms of prediction and feature selection in extensive simulation settings. In addition, our method is illustrated in the analysis of genomic data from a cancer study, demonstrating its advantage in generating biologically meaningful results and identifying potentially important features.

Indexed as

Bayesian support vector machineIsing priorknowledge-guidedpathway graph informationSpike-and-slab prior

Identifiers

PMID31041431
PMCPMC6486656

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.