Evidence map›Paper›PMID 31041379›Full record

ArticleACS central science2019

Discovery of Volatile Biomarkers of Parkinson's Disease from Sebum.

Drupad K Trivedi, Eleanor Sinclair, Yun Xu, Depanjan Sarkar, Caitlin Walton-Doyle, Camilla Liscio, Phine Banks, Joy Milne, Monty Silverdale, Tilo Kunath and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 167 citations in OpenAlex.

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  13. Trained dogs can detect the odor of Parkinson's disease.Journal of Parkinson's disease · 2025
    Article
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Drupad K TrivediManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Eleanor SinclairManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Yun XuManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Depanjan SarkarManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Caitlin Walton-DoyleManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Camilla LiscioAnatune, 4 Wellbrook Way, Girton, Cambridge, U.K., CB3 0NA.
Phine BanksAnatune, 4 Wellbrook Way, Girton, Cambridge, U.K., CB3 0NA.
Joy MilneManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Monty SilverdaleDepartment of Neurology, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester, U.K., M6 8HD.
Tilo KunathInstitute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh, U.K., EH16 4UU.
Royston GoodacreManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
Perdita BarranManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Princess Street, Manchester, U.K., M1 7DN.
University of Manchester · GBUniversity of Liverpool · GBManchester Academic Health Science Centre · GBUniversity of Edinburgh · GB

Funding

Parkinson's UK K-1504
6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive, neurodegenerative disease that presents with significant motor symptoms, for which there is no diagnostic chemical test. We have serendipitously identified a hyperosmic individual, a "Super Smeller" who can detect PD by odor alone, and our early pilot studies have indicated that the odor was present in the sebum from the skin of PD subjects. Here, we have employed an unbiased approach to investigate the volatile metabolites of sebum samples obtained noninvasively from the upper back of 64 participants in total (21 controls and 43 PD subjects). Our results, validated by an independent cohort (

Identifiers

PMID31041379
PMCPMC6487537
OpenAlexW2901548714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.