Evidence map›Paper›PMID 31041359›Full record

ArticleOpen forum infectious diseases2019

A Clinical Prediction Tool for Extended-Spectrum Cephalosporin Resistance in Community-Onset Enterobacterales Urinary Tract Infection.

Erica J Weinstein, Jennifer H Han, Ebbing Lautenbach, Irving Nachamkin, Charles Garrigan, Warren B Bilker, Lois Dankwa, Mary Wheeler, Pam Tolomeo, Judith A Anesi and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Erica J WeinsteinDivision of Infectious Diseases, Department of Medicine.
Jennifer H HanDivision of Infectious Diseases, Department of Medicine.
Ebbing LautenbachDivision of Infectious Diseases, Department of Medicine.
Irving NachamkinDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4811-9716
Charles GarriganDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Warren B BilkerCenter for Clinical Epidemiology and Biostatistics.ORCID 0000-0002-2704-7525
Lois DankwaCenter for Clinical Epidemiology and Biostatistics.ORCID 0000-0002-0259-9550
Mary WheelerCenter for Clinical Epidemiology and Biostatistics.
Pam TolomeoCenter for Clinical Epidemiology and Biostatistics.
Judith A AnesiDivision of Infectious Diseases, Department of Medicine.ORCID 0000-0001-6671-4557
CDC Prevention Epicenters Program
Center for Clinical Research (United States) · USOffice of Infectious Diseases · USUniversity of Pennsylvania · US

Funding

Multi-Drug Resistant Urinary Tract Infections in Ambulatory SettingsR18HS020002 · AHRQ · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2010 to 2012
$1.5M
Mentoring and patient-oriented research in antimicrobial resistanceK24AI080942 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2009 to 2013
$853k
Impact of donor bacterial infections on solid organ transplant recipient outcomesK01AI137317 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ANESI, JUDITH · 2019 to 2023
$722k
Carbapenem-Resistant Klebsiella Pneumoniae in Long-Term Acute Care HospitalsK01AI103028 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAN, JENNIFER · 2013 to 2017
$669k
ACL HHS U54CK000163AHRQ HHS R18 HS020002NCEZID CDC HHS U54 CK000163NIAID NIH HHS K01 AI103028NIAID NIH HHS K01 AI137317NIAID NIH HHS K24 AI080942NIAID NIH HHS L30 AI133754
6 · The paper itself

Abstract

backgroundBacterial resistance to first line antibiotics used to treat community-onset urinary tract infections (UTIs) continues to increase. We sought to create a clinical prediction tool for community-onset UTIs due to extended-spectrum cephalosporin-resistant (ESC-R) Enterobacterales (formerly Enterobacteriaceae, EB).

methodsA case-control study was performed. The source population included patients presenting to an emergency department (ED) or outpatient practice with an EB UTI between 2010 and 2013. Case patients had ESC-R EB UTIs. Control patients had ESC-susceptible EB UTIs and were matched to cases 1:1 on study year. Multivariable conditional logistic regression was performed to develop the predictive model by maximizing the area under the receiver-operating curve (AUC). Internal validation was performed via bootstrapping.

resultsA total of 302 patients with a community-onset EB UTI were included, with 151 cases and 151 controls. After multivariable analysis, we found that presentation with an ESC-R EB community-onset UTI could be predicted by the following: (1) a history of malignancy; (2) a history of diabetes; (3) recent skilled nursing facility or hospital stay; (4) recent trimethoprim-sulfamethoxazole exposure; and (5) pyelonephritis at the time of presentation (AUC 0.73, Hosmer-Lemeshow goodness-of-fit

conclusionsCommunity-onset ESC-R EB UTI can be predicted using the proposed scoring system, which can help guide diagnostic and therapeutic interventions.

Indexed as

community-onsetEnterobacteralesextended-spectrum cephalosporin resistanceprediction toolurinary tract infection

Identifiers

PMID31041359
PMCPMC6483753
OpenAlexW2931203479

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.