Evidence map›Paper›PMID 31041355›Full record

ArticleOpen forum infectious diseases2019

Primary Incidence of Hepatitis C Virus Infection Among HIV-Infected Men Who Have Sex With Men in San Diego, 2000-2015.

Antoine Chaillon, Xiaoying Sun, Edward R Cachay, David Looney, David Wyles, Richard S Garfein, Thomas C S Martin, Sonia Jain, Sanjay R Mehta, Davey M Smith and 2 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Predictors of Acute HCV Incidence in People with HIV: Insights from a Long-term Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antoine ChaillonDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
Xiaoying SunBiostatistics Research Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California.
Edward R CachayDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
David LooneyDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
David WylesDivision of Infectious Diseases, Denver Health Medical Center, Denver, Colorado.
Richard S GarfeinDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
Thomas C S MartinDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
Sonia JainBiostatistics Research Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California.
Sanjay R MehtaDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
Davey M SmithDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
Susan J LittleDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.
Natasha K MartinDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California.

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Mitchell Smith · 1994 to 2026
$78.4M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
Modeling Structural HIV Determinants in Substance Users and related populationsR01DA037773 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTIN, NATASHA, STRATHDEE, STEFFANIE A. · 2015 to 2017
$1.4M
NIAID NIH HHS P30 AI036214NIAID NIH HHS R24 AI067039NIAID NIH HHS R24 AI106039NIAID NIH HHS T32 AI007384NIDA NIH HHS R01 DA037773
6 · The paper itself

Abstract

backgroundLittle is known about the hepatitis C virus (HCV) epidemic among HIV-infected men who have sex with men (HIV+ MSM) in the United States. In this study, we aimed to determine the incidence of primary HCV infection among HIV+ MSM in San Diego, California.

methodsWe performed a retrospective cohort analysis of HCV infection among HIV+ MSM attending 2 of the largest HIV clinics in San Diego. Incident HCV infection was assessed among HIV+ MSM with a negative anti-HCV test and subsequent HCV test between 2000 and 2017, with data censored to 2015. HCV reinfection was assessed among HIV+ MSM successfully treated for HCV between 2008 and 2015. Infection/reinfection rates were calculated using person-time methods.

resultsAmong 3068 initially HCV-seronegative HIV+ MSM, 178 new infections occurred over 15 796 person-years, giving an incidence of 1.13 per 100 person-years (/100py; 95% confidence interval [CI], 0.97-1.31). Incidence was stable from 2000 to 2014 (0.83/100py; 95% CI, 0.41-1.48), with an increase to 3.01/100py (95% CI, 1.97-4.42) in 2015 (

conclusionsHCV incidence is high among HIV+ MSM in San Diego, with evidence suggesting a recent increase in 2015. Strong HCV testing guidelines and active prevention efforts among HIV+ MSM are urgently needed that include rapid diagnosis, treatment, and risk reduction.

Indexed as

HCVHIVincidencemen who have sex with men

Identifiers

PMID31041355
PMCPMC6483132

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.