ArticleOpen forum infectious diseases2019
The Effect of Influenza Vaccination on Mortality and Risk of Hospitalization in Patients With Heart Failure: A Systematic Review and Meta-analysis.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Prevention of Respiratory Syncytial Virus Infection in Healthy Adults by a Single Immunization of Ad26.RSV.preF in a Human Challenge Study.The Journal of infectious diseases · 2022Trial
- Trends and Characterization of Hospitalizations with Heart Failure in Italy Before and During the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2026Article
- Influenza vaccination in patients with heart failure: comprehensive review of evidence, challenges, and clinical implications.Heart failure reviews · 2026Review
- Article
- Effect of Influenza Vaccination on Mortality and Heart Failure Hospitalization in Heart Failure Patients.Vaccines · 2025Article
- The Impact of Vaccinations Against Respiratory Infections on the Prognosis in Heart Failure Patients.Vaccines · 2024Review
- Flu Vaccination Among Patients with Noncommunicable Diseases: A Survey About Awareness, Usage, Gaps and Barriers in Europe.Patient preference and adherence · 2024Article
- The need for vaccination in adults with chronic (noncommunicable) diseases in India - lessons from around the world.Human vaccines & immunotherapeutics · 2022Article
- Influenza vaccination and mortality among adults with heart failure in an integrated healthcare delivery system, 2009-2018.Journal of general internal medicine · 2022Observational
- Epidemic situation of the complex seasonality of imported influenza A and B virus transmission in Guangxi ports of ChinaTurkish journal of medical sciences · 2021Article
- A comparison of epidemiology and clinical outcomes between influenza A H1N1pdm09 and H3N2 based on multicenter surveillance from 2014 to 2018 in South Korea.Influenza and other respiratory viruses · 2021Article
- Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality.Ageing research reviews · 2020Review
- Adult Immunization in Occupational Settings: A Consensus of Indian Experts.Indian journal of occupational and environmental medicineReview
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza is a major cause of morbidity and mortality in patients diagnosed with heart failure. The aim of this study was to evaluate the effectiveness of influenza vaccination in this population in terms of reduction in all-cause mortality and rate of hospitalization.
methodsWe conducted a systematic review and meta-analysis using PubMed and EMBASE entries from January of 2000 through April 2018. Publication bias was examined using the Egger's regression test. Statistical heterogeneity was examined using the Higgins
resultsWe identified 8 studies that included a total of 82 354 patients with heart failure. In patients with heart failure who were vaccinated against influenza, we found a reduced risk of all-cause mortality (hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.51-0.87). No evidence of publication bias was found, and the effect was more pronounced during influenza season (HR, 0.49; 95% CI, 0.30-0.69), compared with noninfluenza season (HR, 0.79; 95% CI, 0.68-0.89). In terms of heart failure hospitalizations, we did not identify a statistically significant difference between the cohorts (HR, 0.62; 95% CI, 0.00-1.23).
conclusionsInfluenza vaccination was associated with a decreased risk of all-cause mortality in patients with heart failure, and this effect was more prominent during the influenza season.
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