Evidence map›Paper›PMID 31041344›Full record

ArticleOpen forum infectious diseases2019

National and International Dimensions of Human Immunodeficiency Virus-1 Sequence Clusters in a Northern California Clinical Cohort.

Soo-Yon Rhee, Brittany R Magalis, Leo Hurley, Michael J Silverberg, Julia L Marcus, Sally Slome, Sergei L Kosakovsky Pond, Robert W Shafer

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Soo-Yon RheeDivision of Infectious Diseases, Department of Medicine, Stanford University, California.
Brittany R MagalisDepartment of Biology, Temple University, Philadelphia, Pennsylvania.
Leo HurleyDivision of Research, Kaiser Permanente Northern California, Oakland.
Michael J SilverbergDivision of Research, Kaiser Permanente Northern California, Oakland.
Julia L MarcusHarvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Sally SlomeDepartment of Infectious Diseases, Kaiser Permanente Northern California, Oakland.
Sergei L Kosakovsky PondDepartment of Biology, Temple University, Philadelphia, Pennsylvania.
Robert W ShaferDivision of Infectious Diseases, Department of Medicine, Stanford University, California.
Kaiser Permanente · USStanford University · USTemple University · USHarvard Pilgrim Health Care · US

Funding

HIV Drug Resistance DatabaseR24AI136618 · NIAID · STANFORD UNIVERSITY · PI ROBERT William SHAFER · 2018 to 2026
$7.3M
PUBLIC HIV DRUG RESISTANCE DATABASER01AI068581 · NIAID · STANFORD UNIVERSITY · PI SHAFER, ROBERT WILLIAM · 2006 to 2017
$6.2M
Turning big data analysis infrastructure for HIV researchR01AI134384 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI NEKRUTENKO, ANTON, POND, SERGEI L KOSAKOVSKY · 2017 to 2021
$4.2M
Modeling Epidemic Infectious Diseases Using Sequence AnalysisU01GM110749 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POND, SERGEI L KOSAKOVSKY · 2014 to 2018
$3.0M
HyPhy: Molecular Evolutionary AnalysesR01GM093939 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI MUSE, SPENCER V., POND, SERGEI L KOSAKOVSKY · 2010 to 2018
$2.5M
PUBLIC HIV DRUG RESISTANCE DATABASER56AI068581 · NIAID · STANFORD UNIVERSITY · PI SHAFER, ROBERT WILLIAM · 2013 to 2013
$729k
Optimizing Care for HIV/HCV-Coinfected Patients in the New HCV Treatment EraK01AI122853 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI MARCUS, JULIA L. · 2016 to 2020
$655k
NIAID NIH HHS K01 AI122853NIAID NIH HHS R01 AI068581NIAID NIH HHS R01 AI134384NIAID NIH HHS R24 AI136618NIAID NIH HHS R56 AI068581NIGMS NIH HHS R01 GM093939NIGMS NIH HHS U01 GM110749
6 · The paper itself

Abstract

backgroundRecent advances in high-throughput molecular epidemiology are transforming the analysis of viral infections.

methodsHuman immunodeficiency virus (HIV)-1

resultsTwenty-five percent of NCC sequences were included in 264 clusters linked to a published sequence, and approximately one third of these (8.0% of the total) were linked to 1 or more non-US sequences. The largest cluster, containing 512 NCC sequences (11.2% of the total), comprised the subtype B lineage that traced its origin to the earliest North American sequences. Approximately 5 percent of NCC sequences belonged to a non-B subtype, and these were more likely to cluster with a non-US sequence. Twenty-two NCC sequences belonged to 1 of 4 large clusters containing sequences from rapidly growing regional epidemics: CRF07_BC (East Asia), subtype A6 (former Soviet Union), a Japanese subtype B lineage, and an East/Southeast Asian CRF01_AE lineage. Bayesian phylogenetics suggested that most non-B sequences resulted from separate introductions but that local spread within the largest CRF01_AE cluster occurred twice.

conclusionsThe NCC contains national and international links to previously published sequences including many to the subtype B strain that originated in North America and several to rapidly growing Asian epidemics. Despite their rapid regional growth, the Asian epidemic strains demonstrated limited NCC spread.

Indexed as

HIV-1network analysispol sequencetransmission

Identifiers

PMID31041344
PMCPMC6483754
OpenAlexW2921019834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.