Evidence map›Paper›PMID 31041341›Full record

ArticleOpen forum infectious diseases2019

Prognostic Power of Pathogen Cell-Free DNA in

Alessander O Guimaraes, Johnny Gutierrez, Stacey A Maskarinec, Yi Cao, Kyu Hong, Felicia Ruffin, Montserrat Carrasco-Triguero, Melicent C Peck, Vance G Fowler, Amos Baruch and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Time to Staphylococcus aureus Blood Culture Positivity as a Risk Marker of Infective Endocarditis: A Retrospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Risk stratification biomarkers forClinical & translational immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alessander O GuimaraesBiomarker Discovery, Genentech, Inc., South San Francisco, California.
Johnny GutierrezBiomarker Development, Genentech, Inc., South San Francisco, California.
Stacey A MaskarinecDivision of Infectious Diseases, Duke University Division of Infectious Diseases, Durham, North Carolina.
Yi CaoBioinformatics and Computational Biology, Genentech, Inc., South San Francisco, California.
Kyu HongBioanalytical Sciences, Genentech, Inc., South San Francisco, California.
Felicia RuffinDivision of Infectious Diseases, Duke University Division of Infectious Diseases, Durham, North Carolina.
Montserrat Carrasco-TrigueroBioanalytical Sciences, Genentech, Inc., South San Francisco, California.
Melicent C PeckClinical Sciences, Genentech, Inc., South San Francisco, California.
Vance G FowlerDivision of Infectious Diseases, Duke University Division of Infectious Diseases, Durham, North Carolina.
Amos BaruchBiomarker Development, Genentech, Inc., South San Francisco, California.
Carrie M RosenbergerBiomarker Discovery, Genentech, Inc., South San Francisco, California.ORCID 0000-0002-8189-8822
Duke University · US

Funding

Institutional Career Development CoreKL2TR002554 · NCATS · DUKE UNIVERSITY · PI SVETKEY, LAURA P · 2018 to 2022
$8.2M
Host Susceptibility to S. aureusR01AI068804 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2007 to 2016
$6.9M
Mentoring Patient Oriented Research in Antibiotic-Resistant BacteriaK24AI093969 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2011 to 2020
$1.6M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
NCATS NIH HHS KL2 TR002554NIAID NIH HHS K24 AI093969NIAID NIH HHS R01 AI068804NIH HHS S10 OD018164
6 · The paper itself

Abstract

background

methods

resultsHigh levels of

conclusionsMeasurements of bacterial load by PCR are a clinically feasible candidate biomarker for stratifying patients at higher risk for complications and poor outcomes. Their diagnostic and prognostic value for identifying foci of infection and influencing treatment remain to be evaluated in additional cohorts.

Indexed as

bacteremiacell-free DNAprognostic biomarkersStaphylococcus aureus

Identifiers

PMID31041341
PMCPMC6483138
OpenAlexW2922430353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.