ArticleWorld journal of orthopedics2019
Investigational growth factors utilized in animal models of spinal fusion: Systematic review.
Article in World journal of orthopedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).International journal of molecular medicine · 2025Review
- A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor.Biomaterials · 2023Article
- Creation and preclinical evaluation of a novel mussel-inspired, biomimetic, bioactive bone graft scaffold: direct comparison with Infuse bone graft using a rat model of spinal fusion.Journal of neurosurgery. Spine · 2023Article
- Therapeutics for enhancement of spinal fusion: A mini review.Journal of orthopaedic translation · 2021Review
- Lumbar Interbody Fusion Conducted on a Porcine Model with a Bioresorbable Ceramic/Biopolymer Hybrid Implant Enriched with Hyperstable Fibroblast Growth Factor 2.Biomedicines · 2021Article
- Trends in lumbar spinal fusion-a literature review.Journal of spine surgery (Hong Kong) · 2020Review
- Oxysterols as promising small molecules for bone tissue engineering: Systematic review.World journal of orthopedics · 2020Article
- Pre-Clinical Evaluation of Biological Bone Substitute Materials for Application in Highly Loaded Skeletal Sites.Biomolecules · 2020Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOver 400000 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current "gold standard" treatment. Tissue engineering has the potential to solve this problem
aimTo review all published studies assessing investigational growth factors for spinal fusion in animal models and identify promising agents for translation.
methodsWe conducted a systematic review of the literature using PubMed, Embase, Cochrane Library, and Web of Science databases with searches run on May 29
resultsTwenty-six articles were included in this study, comprising 14 experimental growth factors: AB204 (
conclusionSeveral promising investigational growth factors for spinal fusion have been identified herein; directly comparing the fusion efficacy and safety of these agents may inform clinical translation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.